返回 
加入收藏
辛伐他汀对脑梗死患者神经功能及预后的影响
x
请在关注微信后，向客服人员索取文件
| 篇名： | 辛伐他汀对脑梗死患者神经功能及预后的影响 |
| TITLE： | |
| 摘要： | 目的：探讨辛伐他汀对脑梗死患者神经功能及预后的影响。方法：选取2015年1月－2016年7月我院收治的脑梗死患者82例，依据随机数字表法分为观察组和对照组，各41例。对照组患者接受常规溶栓治疗，并口服阿司匹林肠溶片100 mg，qd；观察组在对照组基础上睡前口服辛伐他汀片10 mg，qd。治疗1个月后，比较两组患者预后、不良事件发生情况及治疗前后美国国立卫生研究院卒中量表（NIHSS）评分，并对患者的临床资料进行多因素Logistic回归分析。结果：观察组患者预后良好率为80.49％，显著高于对照组的68.29％，差异有统计学意义（P＜0.05）。观察组患者颅内外血管狭窄、脑心综合征、病死的发生率分别为36.59％、19.51％、0，显著低于对照组的46.34％、36.59％、7.32％，差异均有统计学意义（P＜0.05）。治疗前，两组患者NIHSS评分比较，差异无统计学意义（P＞0.05）；治疗1个月后，两组患者NIHSS评分显著降低，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。年龄＞65岁、入院时NIHSS评分＜4分、合并糖尿病、未使用他汀类药物是影响脑梗死患者生存状况的独立危险因素（P＜0.05）。结论：辛伐他汀能够明显改善脑梗死患者的预后，改善神经功能，降低不良事件发生率，且未使用他汀类药物是影响患者生存状况的独立危险因素。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of simvastatin on neurologic function and prognosis of patients with cerebral infraction. METHODS： A total of 82 patients with cerebral infarction selected from our hospital during Jan. 2015 to Jul. 2016 were divided into observation group and control group according to random number table， with 41 cases in each group. Control group received routine thrombolytic therapy and Aspirin enteric-coated tablets 100 mg orally， qd. Observation group was additionally given Simvastatin tablets 10 mg， qd， on the basis of control group. After 1 month of treatment， prognosis， ADE as well as NIHSS scores before and after treatment were compared between 2 groups. Multiple factor Logistic regression analysis was conducted for clinical information of patients. RESULTS： The excellent rate of prognosis in observation group was 80.49％， which was significantly higher than 68.29％， with statistical significance （P＜0.05）. The incidence of intracranial and extracranial vascular stenosis， brain-heart syndrome and death in observation group were 36.59％， 19.51％， 0， which were significantly lower than 46.34％， 36.59％， 7.32％ of control group， with statistical significance （P＜0.05）. At admission， there was no statistical significance in NIHSS scores between 2 groups （P＞0.05）. After 1 month of treatment， NIHSS scores of 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. Age ＞65 years， NIHSS score ＜4 points at admission， combined diabetes， non-use of statins were independent risk factors which affected the survival of patients with cerebral infarction （P＜0.05）. CONCLUSIONS： Simvastatin can significantly improve the neurologic function and prognosis of patients with cerebral infarction， and reduce the incidence of ADE. Non-use of statins is an independent risk factor which affects the survival of patients. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 王映林，李青叶 |
| AUTHORS： | WANG Yinglin，LI Qingye |
| 关键字： | 他汀类药物；脑梗死；神经功能；预后 |
| KEYWORDS： | Statins； Cerebral infarction； Neurologic function； Prognosis |
| 阅读数： | 459 次 |
| 本月下载数： | 3 次 |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！
