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丁苯酞对老年高血压性脑出血钻孔引流术治疗后神经功能及预后的影响
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| 篇名： | 丁苯酞对老年高血压性脑出血钻孔引流术治疗后神经功能及预后的影响 |
| TITLE： | |
| 摘要： | 目的：探讨丁苯酞氯化钠注射液对老年高血压性脑出血（HICH）钻孔引流术治疗后神经功能及预后的影响。方法：选取2015年1月－2016年6月我院收治的老年HICH患者80例作为研究对象，按照随机数字表法分为对照组和观察组，各40例。两组患者均接受钻孔引流术治疗，对照组患者术后给予常规治疗；观察组患者于术后第5天在对照组基础上给予丁苯酞氯化钠注射液100 mL，ivgtt，bid。两组患者均治疗14 d。观察两组患者临床疗效和两组存活患者术前及术后28 d中国脑卒中临床神经功能缺损程度评分量表（CSS）评分，比较两组患者术前及术后14 d脑水肿体积、血清同型半胱氨酸（HCY）和P物质（SP）水平。结果：两组患者各病死1例，观察组患者临床总有效率为87.5％ ，显著高于对照组的67.5％，差异有统计学意义（P＜0.05）。术前，两组存活患者CSS评分、脑水肿体积、血清HCY、SP水平比较，差异均无统计学意义（P＞0.05）；术后28 d，两组存活患者CSS评分显著降低，术后14 d，两组患者SP水平显著升高，血清HCY水平显著降低，脑水肿体积显著缩小，且观察组患者上述指标显著优于对照组，差异均有统计学意义（P＜0.05）。结论：丁苯酞氯化钠注射液能显著提高老年HICH患者钻孔引流术后的临床疗效，改善神经功能缺损，减轻术后脑水肿，并且能够降低血清HCY水平，提高SP水平。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Butylphthalide and sodium chloride injection on neurological function and prognosis of elderly patients with hypertensive intracerebral hemorrhage （HICH） after trepanation and drainage surgery. METHODS： During Jan. 2015 to Jun. 2016， 80 elderly HICH patients were selected from our hospital and then divided into control group and observation group according to random number table， with 40 cases in each group. Both group received trepanation and drainage surgery. Control group was given routine treatment. Observation group was given Butylphthalide and sodium chloride injection 100 mL， ivgtt， bid， on the fifth day after surgery， on the basis of control group. Both groups received treatment for 14 d. Clinical efficacies of 2 groups were observed. CSS scores were compared between 2 groups before surgery and 28 d after operation； volume of encephaledema， serum levels of homocysteine （HCY） and substance P （SP） were compared between 2 groups before surgery and 14 d after operation. RESULTS： The total response rate of observation group was 87.5％， which was significantly higher than 67.5％ of control group， with statistical significance （P＜0.05）. Before surgery， there was no statistical significance in CSS scores， volume of encephaledema or serum levels of HCY and SP between 2 groups （P＞0.05）. CSS scores 28 d after operation， SP levels 14 d after operation were significanthy increased， volume of encephaledema and serum levels of HCY in 2 groups were significantly decreased， and the observation group was significantly better than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Butylphthalide and sodium chloride injection can significantly improve clinical efficacy and hepatic function damage， relieve postoperative encephaledema， reduce serum levels of HCY and increase SP levels in elderly HICH patients after trepanation and drainage surgery. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 贾耀辉，陈慧敏，郭贤利，高永开，代永庆 |
| AUTHORS： | JIA Yaohui，CHEN Huimin，GUO Xianli，GAO Yongkai，DAI Yongqing |
| 关键字： | 丁苯酞氯化钠注射液；钻孔引流术；老年；高血压性脑出血；脑水肿；同型半胱氨酸；P物质 |
| KEYWORDS： | Butylphthalide and sodium chloride injection； Trepanation and drainage surgery； Elderly； Hypertensive intracerebral hemorrhage； Encephaledema； Homocysteine； Substance P |
| 阅读数： | 346 次 |
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