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苍附导痰汤联合氯米芬对多囊卵巢综合征合并不孕症患者性激素水平及子宫内膜容受性的影响
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| 篇名： | 苍附导痰汤联合氯米芬对多囊卵巢综合征合并不孕症患者性激素水平及子宫内膜容受性的影响 |
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| 摘要： | 目的：探讨苍附导痰汤联合枸橼酸氯米芬胶囊对多囊卵巢综合征（PCOS）合并不孕症患者血清性激素水平及子宫内膜容受性的影响。方法：选取2014年1月－2014年12月在贵阳中医学院第一附属医院确诊为PCOS合并不孕症的患者116例，按照随机数字表法分为观察组和对照组，各58例。两组患者均于月经第5天起给予调节激素水平治疗，对照组同时给予枸橼酸氯米芬胶囊50 mg，qd；观察组患者在对照组基础上加服苍附导痰汤1剂，水煎取汁400 mL，bid，两组患者均治疗3个月经周期。比较两组患者治疗前后血清性激素水平[雌二醇（E2）、黄体生成素（LH）]、子宫内膜厚度（Em）、子宫内膜螺旋动脉搏动指数（PI） 、阻力指数（RI），随访1年比较两组患者排卵率及妊娠率。 结果：治疗前，两组患者E2、LH、Em、PI、RI比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者E2、LH、Em水平显著升高，PI、RI显著降低，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。随访1 年，两组患者排卵率（77.59％ vs. 72.41％）比较，差异无统计学意义（P＞0.05）；观察组患者妊娠率为41.38％，显著高于对照组的22.41％，差异有统计学意义（P＜0.05）。结论：苍附导痰汤联合枸橼酸氯米芬胶囊能有效调节PCOS合并不孕症患者的血清性激素水平，改善子宫内膜容受性，从而提高妊娠率。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Cangfu daotan decoction combined with Clomiphene citrate capsule on sex hormone level and endometrial receptivity in patients with polycystic ovary syndrome （PCOS） combined infertility. METHODS： A total of 116 PCOS patients with infertility in the First Affiliated Hospital of Guiyang College of TCM from Jan. 2014 to Dec. 2014 were divided into observation group and control group according to random number table， with 58 cases in each group. Both groups received hormone regulation therapy since the fifth day of menstruation. Control group was given Clomiphene citrate capsule 50 mg， qd； observation group was additionally given one dose of Cangfu daotan decoction， 400 mL after decocted with water， bid， on the basis of control group. Both groups were treated for 3 cycles of menstruation. The levels of serum sex hormone （E2， LH）， endometrial thickness （Em）， endometrial spiral arterial pulsatility index （PI） and resistance index （RI） were compared between 2 groups before and after treatment. The ovulation rate and pregnancy rate were compared between 2 groups after 1-year follow-up. RESULTS： Before treatment， there was no statistical significance in E2， LH， Em， PI or RI between 2 groups （P＞0.05）. After treatment， the levels of E2 and LH as well as Em in 2 groups were increased significantly， while PI and RI were decreased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.06）. After 1-year follow-up， there was no statistical significance in ovulation rate between 2 groups （P＞0.05）. The pregnancy rate of observation group was 41.38％， which was significantly higher than that of control group （22.41％）， with statistical significance （P＜0.05）. CONCLUSIONS： Cangfu daotan decoction combined with Clomiphene citrate capsule can effectively regulate serum sex hormone levels of PCOS patients with infertility， and improve endometrial receptivity so as to increase pregnancy rate. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 李杏英，杨勤，王琪 |
| AUTHORS： | LI Xingying，YANG Qin，WANG Qi |
| 关键字： | 多囊卵巢综合征；不孕症；苍附导痰汤；氯米芬；性激素；子宫内膜容受性 |
| KEYWORDS： | Polycystic ovarian syndrome； Infertility； Cangfu daotan decoction； Clomiphene； Sex hormone； Endometrial receptivity |
| 阅读数： | 287 次 |
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