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灯盏花素联合长春西汀治疗急性脑梗死的临床观察
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| 篇名： | 灯盏花素联合长春西汀治疗急性脑梗死的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨灯盏花素联合长春西汀治疗急性脑梗死的临床疗效及安全性。方法：选取2014年1月－2015年12月我院收治的急性脑梗死患者80例作为研究对象，按照随机数字表法分为对照组和观察组，各40例。对照组患者给予长春西汀注射液20 mL+ 0.9％氯化钠注射液250 mL，ivgtt，qd；观察组患者在对照组基础上间隔2～3 h给予灯盏花素注射液20 mL+5％葡萄糖注射液250 mL，ivgtt，qd。两组患者均治疗2周。观察两组患者的临床疗效，治疗前后的血清和肽素、N端前脑钠肽（NT-proBNP）、白蛋白钴结合（ACB）值以及欧洲卒中量表 （ESS） 和功能独立性评定（FIM）评分，并记录不良反应发生情况。结果：观察组患者临床总有效率（90.0％）明显高于对照组（67.5％），差异有统计学意义（P＜0.05）。治疗前，两组患者血清和肽素、NT-proBNP、ACB值和ESS、FIM评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者血清和肽素和NT-proBNP水平均明显降低，ACB值、ESS和FIM评分明显升高，且观察组患者改善情况均明显优于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗过程中未见明显的不良反应发生。结论：灯盏花素联合长春西汀可明显改善急性脑梗死患者的神经功能，临床疗效较好，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy and safety of breviscapine combined with vinpocetine in the treatment of acute cerebral infraction. METHODS： A total of 80 patients with acute cerebral infraction were selected from our hospital during Jan. 2014-Dec. 2015， and then divided into observation group and control group according to random number table， with 40 cases in each group. Control group was given Vinpocetine injection 20 mL+0.9％ Sodium chloride injection 250 mL， ivgtt， qd. Observation group was additionally given Breviscapine injection 20 mL+5％ Glucose injection 250 mL， ivgtt， qd， at intervals of 2-3 h on the basis of control group. Both groups were treated for 2 weeks. Clinical efficacies as well as serum copeptin， NT-proBNP， albumin cobalt binding （ACB） value， European stroke scale （ESS） and functional independence measurement （FIM） score before and after treatment were observed in 2 groups， and the occurrence of ADR was recorded. RESULTS： Total response rate of observation group （90.0％） was significantly higher than that of control group （67.5％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in serum peptide， NT-proBNP， ACB value， ESS or FIM score between 2 groups （P＞0.05）. After treatment， serum copeptin and NT-proBNP levels of 2 groups were decreased significantly， while ACB value， ESS and FIM score were increased significantly； the improvement of observation group was significantly better than that of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Breviscapine combined with vinpocetine can improve neurological function of acute cerebral infraction patients and show good therapeutic efficacy with good safety. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 冯诗婷，李丽，林云 |
| AUTHORS： | FENG Shiting，LI Li，LIN Yun |
| 关键字： | 灯盏花素；长春西汀；急性脑梗死；和肽素；N端前脑钠肽；缺血修饰性白蛋白 |
| KEYWORDS： | Breviscapine； Vinpocetine； Acute cerebral infarction； Copeptin； NT-proBNP； Ischemia modified albumin |
| 阅读数： | 463 次 |
| 本月下载数： | 1 次 |
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