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补肾散寒通络汤联合艾灸及塞来昔布治疗膝骨关节炎的临床观察
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| 篇名： | 补肾散寒通络汤联合艾灸及塞来昔布治疗膝骨关节炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察补肾散寒通络汤联合艾灸及塞来昔布治疗膝骨关节炎（KOA）的临床疗效及安全性。方法：选取2014年5月－2015年12月在重庆康华医院就诊的KOA患者70 例， 按照就诊单双号顺序分为对照组和观察组，各35例。对照组患者给予塞来昔布胶囊0.2 g，qd；观察组患者在对照组基础上加用补肾散寒通络汤（每日1剂，水煎取汁300 mL，分早、中、晚3次服用）及艾灸治疗。两组患者均以4周为1个疗程，连续治疗2个疗程。比较两组患者的临床疗效，治疗前后的中医证候积分、视觉模拟评分法（VAS）评分、西安大略和麦克马斯特大学量表（WOMAC）评分、实验室检查指标、关节情况，以及不良反应发生情况。结果：观察组患者的总有效率（85.71％）显著高于对照组（68.57％），差异有统计学意义（P＜0.05）。治疗前，两组患者的上述指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者的中医证候积分、VAS评分、WOMAC评分、红细胞沉降率、C反应蛋白水平和膝关节肿胀积分均较治疗前显著降低，且观察组各指标水平显著低于对照组，差异均有统计学意义（P＜0.05）；两组患者治疗前后骨摩擦音关节个数比较，差异均无统计学意义（P＞0.05）。两组患者不良反应发生率比较（5.71％ vs. 2.86％），差异无统计学意义（P＞0.05）。结论：补肾散寒通络汤联合艾灸及塞来昔布能改善KOA患者临床症状，缓解关节疼痛，减轻关节炎症和肿胀，且用药较安全。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Bushen sanhan tongluo decoction combined with moxibustion and celecoxib in the treatment of knee osteoarthritis （KOA）. METHODS： A total of 70 KOA patients were selected from Chongqing Kanghua Hospital during May 2014-Dec. 2015， and then divided into observation group and control group according to odd and even number， with 35 cases in each group. Control group was given Celecoxib capsule 0.2 g， qd； observation group was additionally given Bushen sanhan tongluo decoction （one dose a day， 300 mL， decocted with water， taking it 3 times in the morning， noon and night） and moxibustion. A treatment course lasted for 4 weeks， and both received 2 courses of treatment. Clinical efficacies as well as TCM syndrome score， VAS score， WOMAC score， lab indexes， joint condition before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： Total response rate of observation group （85.71％） was significantly higher than control group （68.57％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. After treatment， TCM syndrome score， VAS score， WOMAC score， erythrocyte sedimentation rate， CRP level and knee swelling score of 2 groups were decreased significantly， compared to before treatment； those indexes of observation group were significantly lower than those of control group， with statistical significance （P＜0.05）. There was no statistical significance in the number of bone fricative joint between 2 groups before and after treatment （P＞0.05）. There was no statistical significance in the incidence of ADR （5.71％ vs. 2.86％） between 2 groups （P＞0.05）. CONCLUSIONS： Bushen sanhan tongluo decoction combined with moxibustion and celecoxib can improve clinical symptoms， relieve joint pain， joint inflammation and swelling of KOA patients with good safety. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 周滢，舒承倩，唐欣，王桃元，黄英如 |
| AUTHORS： | ZHOU Ying，SHU Chengqian，TANG Xin，WANG Taoyuan，HUANG Yingru |
| 关键字： | 补肾散寒通络汤；艾灸；塞来昔布；膝骨关节炎 |
| KEYWORDS： | Bushen sanhan tongluo decoction； Moxibustion； Celecoxib； Knee osteoarthritis |
| 阅读数： | 325 次 |
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