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米诺环素治疗中重度慢性牙周炎合并2型糖尿病的临床观察
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| 篇名： | 米诺环素治疗中重度慢性牙周炎合并2型糖尿病的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨米诺环素对中重度慢性牙周炎合并2型糖尿病患者的临床指标、炎症因子和血糖的影响。方法：选取我院2013年2月－2015年8月收治的中重度慢性牙周炎合并2型糖尿病患者125例，按照随机数字表法分为对照组（63例）和观察组（62例）。两组患者均给予洁治术和根面平整术等牙周基础治疗；对照组患者术后给予碘甘油注满牙周袋，2～4 次/d；观察组患者术后给予盐酸米诺环素软膏注满牙周袋，每周1次。两组患者均治疗4周。观察两组患者治疗前和治疗后3个月的临床指标[探诊深度、临床附着水平（CAL）和探诊出血率]、血清炎症因子（C反应蛋白和肿瘤坏死因子α）、血糖（空腹血糖和糖化血红蛋白）水平，并记录不良反应发生情况。结果：治疗前，两组患者临床指标、血清炎症因子和血糖水平比较，差异均无统计学意义（P＞0.05）。治疗后3个月，两组患者探诊深度、探诊出血率和血清炎症因子水平均明显降低，且观察组明显低于对照组，差异均有统计学意义（P＜0.05）；两组患者CAL均较治疗前增加，但治疗前后比较、组间比较差异均无统计学意义（P＞0.05）；两组患者空腹血糖均明显降低，差异有统计学意义（P＜0.05），但组间比较差异无统计学意义（P＞0.05）；对照组患者糖化血红蛋白水平较治疗前降低，但差异无统计学意义（P＞0.05）；观察组患者糖化血红蛋白水平明显降低，且观察组明显低于对照组，差异有统计学意义（P＜0.05）。观察组患者不良反应发生率（3.23％）与对照组（0）比较，差异无统计学意义（P＞0.05）。结论：米诺环素治疗中重度慢性牙周炎合并2型糖尿病可有效改善患者牙周炎的临床指标，降低血清炎症因子和血糖水平，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of minocycline on clinical indexes， inflammatory factors and blood glucose of patients with moderate and severe chronic periodontitis complicated with type 2 diabetes （T2DM）. METHODS： A total of 125 patients with moderate and severe chronic periodontitis complicated with T2DM selected from our hospital during Feb. 2013-Aug. 2015 were divided into control group （63 cases） and observation group （62 cases） according to random number table. Both groups were periodental non-surgical treatment as scaling and root planning. Control group was given iodine glycerin to fill periodontal pockets after surgery， 2-4 times/d. Observation group was given Minocycline hydrochloride ointment， once a week， after surgery. Both groups were treated for 4 weeks. The levels of clinical indexes [probing depth， clinical attachment level （CAL）， probing bleeding rate]， serum inflammatory factors （CRP， TNF-α） and blood glucose （fasting blood glucose， glycosylated hemoglobin） were observed in 2 groups before treatment， 3 months after treatment， and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in clinical indexes， serum inflammatory factors and blood glucose levels between 2 groups （P＞0.05）. Three months after treatment， probing depth， probing bleeding rate and serum inflammatory factor levels of 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. Compared to before treatment， CAL of 2 groups were increased， without statistical significance before and after treatment or between 2 groups （P＞0.05）. The levels of fasting blood glucose in 2 groups were decreased， with statistical significance （P＜0.05）， but no statistical significance between 2 groups （P＞0.05）. Compared to before treatment， the level of glycosylated hemoglobin in control group was decreased， without statistical significance （P＞0.05）； the level of glycosylated hemoglobin in observation group was decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between observation group （3.23％） and control group （0） （P＞0.05）. CONCLUSIONS： For moderate and severe chronic periodontitis complicated with T2DM， minocycline effectively improves clinical indexes of periodontitis， reduces serum inflammatory factors and blood glucose with good safety. |
| 期刊： | 2017年第28卷第23期 |
| 作者： | 徐海波，伍松 |
| AUTHORS： | XU Haibo，WU Song |
| 关键字： | 米诺环素；慢性牙周炎；2型糖尿病；炎症因子；血糖 |
| KEYWORDS： | Minocycline； Chronic periodontitis； Type 2 diabetes； Inflammatory factor； Blood glucose |
| 阅读数： | 339 次 |
| 本月下载数： | 3 次 |
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