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布拉氏酵母菌辅助磷酸铝治疗小儿急性腹泻的临床观察
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| 篇名： | 布拉氏酵母菌辅助磷酸铝治疗小儿急性腹泻的临床观察 |
| TITLE： | |
| 摘要： | 目的：考察布拉氏酵母菌辅助磷酸铝对急性腹泻患儿症状体征消失时间、免疫功能及炎症因子水平的影响。方法：选取我院2013年3月－2016年3月收治的急性腹泻患儿110例，按随机数字表法分为对照组和观察组，各55例。对照组患儿在常规治疗基础上给予磷酸铝凝胶2.5 g，po，qd；观察组患儿在对照组基础上加用布拉氏酵母菌胶囊0.25 g，po，bid。两组患儿均治疗3 d。比较两组患儿的临床疗效、症状体征（腹泻、腹痛、呕吐及大便常规异常）消失时间与治疗前后的大便频率、大便性状评分、免疫功能指标（CD3+、CD4+、CD8+、CD4+/CD8+）、炎症因子（白细胞介素6、白细胞介素10、肿瘤坏死因子α）水平，以及不良反应发生情况。结果：观察组患儿的总有效率（90.91％）显著高于对照组（70.91％），各症状体征消失时间显著短于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患儿的大便频率、大便性状评分、免疫功能指标和炎症因子水平比较，差异均无统计学意义（P＞0.05）。治疗后，两组患儿的大便频率、大便性状评分和炎症因子水平均显著低于治疗前，且观察组患儿的大便频率、大便性状评分和炎症因子水平显著低于对照组；CD3+、CD4+、CD4+/CD8+显著高于治疗前及对照组，CD8+显著低于治疗前及对照组，差异均有统计学意义（P＜0.05），但对照组患儿的免疫功能指标在治疗前后比较，差异均无统计学意义（P＞0.05）。对照组和观察组患儿口干和便秘的总发生率分别为5.45％、9.09％，组间比较差异无统计学意义（P＞0.05）。结论：布拉氏酵母菌辅助磷酸铝治疗小儿急性腹泻可显著改善患儿症状体征，缩短病程，提高机体免疫功能，降低炎症反应水平，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the effect of Saccharomyces boulardii adjuvant with aluminium phosphate on symptoms and signs disappearance time， immune function and inflammatory factors in children with acute diarrhea. METHODS： Totally 110 children with acute diarrhea were chosen from our hospital during Mar. 2013-Mar. 2016， and then randomly divided into control group and observation group according to random number table， with 55 cases in each group. Control group was given Aluminium phosphate gel 2.5 g， po， qd， on the basis of conventional treatment. Observation group was additionally given S. boulardii capsules 0.25 g， po， bid， on the basis of control group. Both groups were treated for 3 d. Clinical efficacies， symptoms and signs （diarrhea， abdominal pain， vomiting， abnormal stool routine） disappearance time as well as stool frequency， stool character scores， immune function indexes （CD3+， CD4+， CD8+， CD4+/CD8+）， inflammatory factors （IL-6， IL-10， TNF-α） before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （90.91％） was significantly higher than that of control group （70.91％）； the symptoms and signs disappearance time was significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in stool frequency， stool character scores， immune function indexes or inflammatory factor levels between 2 groups （P＞0.05）. After treatment， stool frequency， stool character scores and inflammatory factor levels of 2 groups were significantly lower than before， and the observation group was significantly lower than the control group； the levels of CD3+， CD4+， CD4+/CD8+ were significantly higher than before treatment and control group， and the level of CD8+ was significantly lower than before treatment and control group， with statistical significance （P＜0.05）. There was no significant difference in immune function indexes of control group before and after treatment（P＞0.05）. Total incidence of dry mouth and constipation was 5.45％ in control group and 9.09％ in observation group， without statistical significance （P＞0.05）. CONCLUSIONS： S. boulardii adjuvant with aluminium phosphate in the treatment of pediatric acute diarrhea can efficiently improve symptoms and signs， shorten disease duration， improve immune function and reduce inflammatory reaction with good safety. |
| 期刊： | 2017年第28卷第23期 |
| 作者： | 王丹，叶悄红，郭琴 |
| AUTHORS： | WANG Dan，YE Qiaohong，GUO Qin |
| 关键字： | 布拉氏酵母菌；磷酸铝；小儿急性腹泻；免疫功能；炎症反应 |
| KEYWORDS： | Saccharomyces boulardii； Aluminium phosphate； Pediatric acute diarrhea； Immune function； Inflammatory reaction |
| 阅读数： | 387 次 |
| 本月下载数： | 3 次 |
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