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重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并HPV亚临床感染的临床观察
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| 篇名： | 重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并HPV亚临床感染的临床观察 |
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| 摘要： | 目的：探讨重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并人乳头瘤病毒（HPV）亚临床感染（SPI）的临床疗效及安全性。方法：选取2014年7月－2015年8月我院妇科门诊收治的宫颈糜烂合并SPI患者207例，按随机数字表法分为A、B、C组，各69例。A组患者于月经周期结束3 d后给予重组人干扰素α2b阴道泡腾胶囊80万IU，阴道后穹窿给药，qd，10 d为1个疗程，治疗3个疗程；B组患者进行射频消融术治疗；C组患者采用同等剂量重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗。所有患者随访半年。评价3组患者临床疗效及B、C组患者术后创面愈合率，术后2周临床症状消失率、并发症发生率，并记录不良反应。结果：B、C组患者宫颈糜烂治疗有效率分别为94.20％、98.55％，显著高于A组的62.32％；C组患者SPI有效率为92.75％，显著高于B组的69.57％和A组的53.62％；C组患者HPV感染有效率为86.96％，显著高于B组的63.77％，差异均有统计学意义（P＜0.05）。B组患者术后4、6、8周创面愈合率分别为10.14％、43.48％、97.10％，C组患者分别为52.17％、92.75％、100.00％；C组患者术后4、6周创面愈合率显著高于B组，差异有统计学意义（P＜0.05）。C组患者术后2周阴道出血和排液等临床症状消失率为81.16％，显著高于B组的43.48％，差异有统计学意义（P＜0.05）。B、C组患者并发症发生率分别为11.60％、4.35％，组间差异无统计学意义（P＞0.05）。两组患者均未见明显不良反应发生。结论：重组人干扰素α2b阴道泡腾胶囊结合射频消融术治疗宫颈糜烂合并SPI疗效较好，创面愈合时间短，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of Recombinant human interferon α2b （rhIFN α2b） vaginal effervescent capsules combined with radiofrequency ablation in the treatment of cervical erosion with human papilloma virus （HPV） subclinical infection （SPI）. METHODS： A total of 207 cervical erosion patients with SPI were selected from gynecology outpatient department of our hospital during Jul. 2014-Aug. 2015 and then divided into group A， B， C according to random number table， with 69 cases in each group. Group A was given rhIFN α2b vaginal effervescent capsules 800 thousand IU， via posterior fornix， qd， 3 days after the end of menstruation， 10 days as a treatment course， for 3 courses. Group B received radiofrequency ablation. Group C was given constant dose of rhIFN α2b vaginal effervescent capsules combined with radiofrequency ablation. The clinical efficacy of 3 groups， the rate of wound healing， the rate of associated symptoms disappearance 2 weeks after surgery and the incidence of complications in group B and C were evaluated. The occurrence of ADR was recorded. RESULTS： The response rates of group B， C were 94.20％ and 98.55％， which were significantly higher than 62.32％ of group A. The response rates of SPI in group C was 92.75％， which was significantly higher than 63.77％ of group B， with statistical significance （P＜0.05）. The wound healing rates of group B 4，6，8 weeks after surgery were 10.14％，43.48％，97.10％； and those of group C were 52.17％，92.75％，100.00％.The wound healing rates of group C 4，6 weeks after surgery were significantly higher than those of group B， with statistical significance（P＜0.05）.The disappearance incidence of symptom as vaginal bleeding and drainage in group C 2 weeks after surgery was 81.16％，which was significantly higher than 43.48％ of group B， with statistical significance （P＜0.05）.The incidences of complications were 11.60％ in group B and 4.35％ in group C，without statistical significance （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： rhIFN α2b vaginal effervescent capsules combined with radiofrequency ablation can effectively improve the efficacy of cervical erosion with SPI， shorten the wound healing time with good safety. |
| 期刊： | 2017年第28卷第23期 |
| 作者： | 郝云涛，郑小影，赵淑敏，张玉娟，李建团，张雅丽 |
| AUTHORS： | HAO Yuntao，ZHENG Xiaoying，ZHAO Shumin，ZHANG Yujuan，LI Jiantuan，ZHANG Yali |
| 关键字： | 重组人干扰素α2b阴道泡腾胶囊；射频消融术；人乳头瘤状病毒；亚临床感染 |
| KEYWORDS： | Recombinant human interferon α2b vaginal effervescent capsules； Radiofrequency ablatio； Human papilloma virus； Subclinical infection |
| 阅读数： | 1064 次 |
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