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阿托伐他汀钙联合普罗布考治疗动脉粥样硬化的临床观察
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| 篇名： | 阿托伐他汀钙联合普罗布考治疗动脉粥样硬化的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨阿托伐他汀钙联合普罗布考治疗动脉粥样硬化的临床疗效及安全性。方法：选取2015年1月－2016年1月就诊于四川中医药高等专科学校附属医院的动脉粥样硬化患者80例，按照随机数字表法分为对照组和观察组，各40例。对照组患者给予普罗布考片0.5 g，每2天服用1次；观察组患者在对照组基础上给予阿托伐他汀钙片20 mg，qd。两组患者均连续服药24周。观察两组患者治疗前后的血脂[三酰甘油（TC）、总胆固醇（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）]水平、动脉斑块面积及厚度，治疗前和治疗结束后3个月的生活质量评分，并记录不良反应发生情况。结果：治疗前，两组患者血脂水平、动脉斑块面积及厚度、生活质量评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者TC、TG、LDL-C水平与动脉斑块面积及厚度均明显下降，HDL-C水平和生活质量评分均明显升高，且观察组患者上述指标改善程度均明显优于对照组，差异均有统计学意义（P＜0.05）。观察组患者总不良反应发生率（12.50％）与对照组（15.00％）比较，差异无统计学意义（P＞0.05）。结论：阿托伐他汀钙联合普罗布考治疗动脉粥样硬化，能降低患者血脂水平、有效溶栓，有利于患者生活能力的恢复，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the clinical efficacy and safety of atorvastatin calcium combined with probucol in the treatment of atherosclerosis. METHODS： A total of 80 patients with atherosclerosis selected from the Affiliated Hospital of Sichuan College of TCM during Jan. 2015-Jan. 2016 were randomly divided into control group and observation group according to random number table， with 40 cases in each group. Control group was given Probucol tablet 0.5 g， every 2 days. Observation group was additionally given Atorvastatin calcium tablet 20 mg， qd， on the basis of control group. Both groups were treated for consecutive 24 weeks. The levels of blood lipid， arterial plaque size and thickness before and after treatment， life quality score before treatment and 3 months after treatment were observed in 2 groups； and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in blood lipid， arterial plaque size and thickness or life quality score between 2 groups （P＞0.05）. After treatment， the levels of TC， TG and LDL-C， arterial plaque size and thickness in 2 groups were decreased significantly， while HDL-C level and life quality score were increased significantly； the improvement of above indexes in observation group was significantly better than control group， with statistical significance （P＜0.05）. There was no statistical significance in total incidence of ADR between observation group （12.50％） and control group （15.00％）（P＞0.05）. CONCLUSIONS： Atorvastatin calcium combined with probucol in the treatment of atherosclerosis can reduce blood lipid level and get thrombolysis， and contribute to the recovery of living ability with good safety. |
| 期刊： | 2017年第28卷第23期 |
| 作者： | 黄正桥，刘建，朱莹 |
| AUTHORS： | HUANG Zhengqiao，LIU Jian，ZHU Ying |
| 关键字： | 阿托伐他汀钙；普罗布考；动脉粥样硬化；血脂；斑块；生活质量评分 |
| KEYWORDS： | Atorvastatin； Probucol； Atherosclerosis； Blood lipid； Plaque； Life quality score |
| 阅读数： | 611 次 |
| 本月下载数： | 2 次 |
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