返回 
加入收藏
葛根素立方液晶的制备及在微针作用下的体外透皮特性研究
x
请在关注微信后，向客服人员索取文件
| 篇名： | 葛根素立方液晶的制备及在微针作用下的体外透皮特性研究 |
| TITLE： | |
| 摘要： | 目的：制备葛根素立方液晶，研究其在微针作用下的体外透皮特性。方法：以单油酸甘油酯、乙醇、葛根素、纯化水为材料，采用注入法制备葛根素立方液晶；用偏光显微镜和小角X射线衍射进行表征。采用改进的Franz扩散池比较葛根素10％乙醇水溶液和葛根素立方液晶的体外透皮特性；考察葛根素立方液晶在微针作用下的体外透皮特性。结果：所制葛根素立方液晶在偏光显微镜下无明显晶体分布，呈暗绿色，显各向同性；其散射峰位之比为[√6] ∶ [√8] ，证明其内部结构为螺旋型晶格。葛根素10％乙醇水溶液和葛根素立方液晶的透皮速率分别为15.306、29.101 μg/（cm2·h），20 h内的累积透皮量分别为190、545 μg/cm2；200 μm微针预处理皮肤后，葛根素立方液晶的透皮速率为78.15 μg/（cm2·h），20 h内的累积透皮量为1 450 μg/cm2。结论：成功制得葛根素立方液晶，其具有较葛根素乙醇水溶液更强的透皮能力，且联合微针给药具有更好的透皮性能。 |
| ABSTRACT： | OBJECTIVE： To prepare the puerarin cubic phase， and study its in vitro transdermal characteristics under microneedle. METHODS： Using glycerol monooleate， ethanol， puerarin and purified water as materials， injection method was used to prepare the puerarin cubic phase. Polarizing microscopy and small angle X-ray diffraction were used for characterizing. The in vitro transdermal characteristics of Puerarin 10％ ethanol solution and puerarin cubic phase were comparatively studied by modified Franz diffusion cell， and the in vitro transdermal characteristics of puerarin cubic phase under microneedle were studied. RESULTS： Prepared puerarin cubic phase had no obvious phase distribution under polarizing microscope with dark green color， showing isotropic trait. The ratio of scattering peak position was [√6] ∶ [√8] ， indicating that its internal structure was spiral lattice. The transdermal rates of Puerarin 10％ ethanol solution and puerarin cubic phase were 15.306， 29.101 μg/（cm2·h）， and the cumulative transdermal amounts within 20 h were 190， 545 μg/cm2， respectively. After the pretreatment on skin by 200 μm microneedle， the transdermal rates of puerarin cubic phase was 78.15 μg/（cm2·h）， and the cumulative transdermal amounts within 20 h was 1 450 μg/cm2. CONCLUSIONS： Puerarin cubic phase is successfully prepared， which shows stronger transdermal ability than puerarin ethanol aqueous solution and better transdermal ability when combined with microneedle administration. |
| 期刊： | 2017年第28卷第22期 |
| 作者： | 莫建民 |
| AUTHORS： | MO Jianmin |
| 关键字： | 葛根素；立方液晶；制备；微针；体外透皮 |
| KEYWORDS： | Puerarin； Cubic phase； Preparation； Microneedle； in vitro transdermal |
| 阅读数： | 456 次 |
| 本月下载数： | 4 次 |
* 注：未经本站明确许可，任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作！
