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枸橼酸坦度螺酮对自发性高血压大鼠血压的影响及机制研究
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| 篇名： | 枸橼酸坦度螺酮对自发性高血压大鼠血压的影响及机制研究 |
| TITLE： | |
| 摘要： | 目的：研究枸橼酸坦度螺酮（TC）对自发性高血压大鼠（SHR）血压的影响及机制。方法：将SHR随机分为模型组、阳性对照组（苯磺酸左旋氨氯地平片，2.5 mg/kg）和TC高、中、低剂量组（TC胶囊，40、20、10 mg/kg），每组8只，另设8只正常大鼠为正常对照组，每天ig药物1次，连续28 d。测量各组大鼠首次给药前及给药后0.5、1、1.5、2、3、4 h的收缩压（SBP），另每给药7 d测量1次1 h的SBP；末次给药后检测血清中一氧化氮（NO）含量，血浆中内皮素、肾素、血管紧张素Ⅱ（AngⅡ）和去甲肾上腺素（NE）含量。结果：单次给药时，与模型组比较，阳性对照组和TC各剂量组SHR首次给药后0.5、1 h时的SBP均明显降低（P＜0.05或P＜0.01），之后仅阳性对照组和TC高剂量组的SBP明显降低（P＜0.05或P＜0.01）；多次给药时，与模型组比较，阳性对照组和TC高、中剂量组SHR给药第7、14、28天的SBP 均明显降低（P＜0.05或P＜0.01）。与模型组比较，阳性对照组和TC高剂量组SHR血清中NO含量明显升高，血浆中内皮素、肾素、AngⅡ和NE含量均明显降低（P＜0.05或P＜0.01）；与阳性对照组比较，TC各剂量组SHR血清中NO含量明显降低，TC中剂量组SHR血浆中内皮素含量明显升高（P＜0.05）。结论：TC可明显降低SHR血压，其机制可能与调节NO和内皮素释放平衡，降低肾素、AngⅡ及NE含量有关。 |
| ABSTRACT： | OBJECTIVE： To study the effect and mechanism of tandospirone citrate （TC） on blood pressure in spontaneously hypertensive rats （SHR）. METHODS： SHR were divided into model group， positive control group （Levamlodipine besylate tablets， 2.5 mg/kg）， TC high-dose， medium-dose， low-dose groups （TC capsules， 40， 20， 10 mg/kg）， 8 in each group. Other 8 normal rats were chosen as normal control group. The rats were intragastrically administrated medicines， once a day， for 28 d. Systolic blood pressure （SBP） before first administration and after 0.5， 1， 1.5， 2， 3， 4 h of administration in each group were measured， and SBP after 1 h of administration were measured once every 7 d. After last administration， nitric oxide （NO） content in serum， endothelin， renin， angiotensin Ⅱ （Ang Ⅱ） and norepinephrine （NE） contents in plasma were detected. RESULTS： In single administration， compared with model group， SBP in 0.5， 1 h in positive control group and TC groups after first administration were obviously decreased （P＜0.05 or P＜0.01）， then SBP were obviously decreased only in positive control group and TC high-dose group （P＜0.05 or P＜0.01）. In multiple administration， compared with model group， SBP in 7th， 14th， 28th day of administration in positive control group and TC high-dose， medium-dose groups were obviously decreased （P＜0.05 or P＜0.01）. Compared with model group， NO content in serum in positive control group， TC high-dose group were obviously increased； endothelin， renin， Ang Ⅱ and NE contents in plasma were obviously decreased （P＜0.05 or P＜0.01）. Compared with positive control group， NO content in serum in TC groups was obviously decreased； endothelin， renin， Ang Ⅱ and NE contents in plasma were obviously increased in TC medium-dose group （P＜0.05）. CONCLUSIONS： TC can obviously decrease the blood pressure of SHR. The mechanism may be associated with adjusting the balance of NO and endothelin， and decreasing renin， Ang Ⅱ and NE contents. |
| 期刊： | 2017年第28卷第22期 |
| 作者： | 周娅，吴建明，黄雪飞，李小莉，叶云 |
| AUTHORS： | ZHOU Ya，WU Jianming，HUANG Xuefei，LI Xiaoli，YE Yun |
| 关键字： | 枸橼酸坦度螺酮；自发性高血压大鼠； 内皮功能 |
| KEYWORDS： | Tandospirone citrate； Spontaneously hypertensive rats； Endothelial function |
| 阅读数： | 395 次 |
| 本月下载数： | 5 次 |
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