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参松养心胶囊联合低剂量胺碘酮治疗室性心律失常的疗效分析
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| 篇名： | 参松养心胶囊联合低剂量胺碘酮治疗室性心律失常的疗效分析 |
| TITLE： | |
| 摘要： | 目的：观察参松养心胶囊联合低剂量胺碘酮治疗室性心律失常的疗效和安全性。方法：回顾性分析106例室性心律失常患者资料，按照用药不同分为对照组和观察组，每组53例。两组患者均予以常规治疗，在此基础上对照组患者给予盐酸胺碘酮片口服治疗（第1周：每次0.2 g，每日3次；第2周：每次0.2 g，每日2次；第3周至疗程结束：每次0.2 g，每日1次）；观察组患者予以盐酸胺碘酮片口服治疗（第1周：每次0.2 g，每日2次；第2周至疗程结束：每次0.2 g，每日1次）+参松养心胶囊1.6 g，口服，每天3次。两组疗程均为8周。观察并比较两组患者临床疗效，血压，心率，心电图中PR间期、QT间期，复律时间以及不良反应发生情况。结果：治疗后，观察组患者总有效率（94.34％）显著高于对照组（81.13％），不良反应发生率（3.77％）显著低于对照组（13.21％），复律时间显著短于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者心率比较，差异无统计学意义（P＞0.05）。治疗后，两组患者心率显著低于同组治疗前，且观察组显著低于对照组，差异有统计学意义（P＜0.05）。两组患者治疗前后血压、PR间期和QT间期比较，差异均无统计学意义（P＞0.05）。结论：在常规治疗基础上，参松养心胶囊联合低剂量胺碘酮治疗室性心律失常疗效较好，可以显著改善患者心率，起效较快，安全性亦较好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of Shensong yangxin capsule combined with low-dose amiodarone in the treatment of ventricular tachyarrhythmia. METHODS： In retrospective analysis， 106 patients with ventricular tachyarrhythmia were divided into control group and observation with 53 cases in each group according to drug use. Based on conventional treatment， control group was additionally given Amiodarone tablet （first week：0.2 g each time，3 times a day；second week：0.2 g each time， 2 times a day； third week to the end of the treatment：0.2 g each time， 1 times a day），orally. Observation group was given Amiodarone tablet （first week： 0.2 g each time， twice a day； second week to the end of the treatment：0.2 g each time， 1 times daily），orally +Shensong yangxin capsule 1.6 g， 3 times a day， orally. Both groups were treated for 8 weeks. Clinical efficacy， blood pressure， heart rate and electrocardiogram （PR period and QT period）and the cardiac cardioversion time were compared between 2 groups， and the occurrence of ADR was also recorded during treatment. RESULTS： After treatment， total response rate of observation group （94.34％） was higher than that of control group （81.13％）， the incidence of ADR was lower than that of control group （3.77％ vs. 13.21％） and the cardiac cardioversion time was shorter than that of control group，with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in heart rate between 2 groups； after treatment， heart rate of 2 groups were significantly lower than before， and observation group was significantly lower than control group，with statistical significance （P＜0.05）. There were no statistical significance in blood pressure、PR period and QT period between 2 groups before and after treatment （P＞0.05）. CONCLUSIONS： Based on conventional treatment， Shensong yangxin capsule combined with low-dose amiodarone have good therapeutic efficacy with rapid response for ventricular arrhythmia，it can significantly improve the heart rate of the patients， and the effect is faster with good safety . |
| 期刊： | 2017年第28卷第21期 |
| 作者： | 王会洪，黄鹤，任贻强 |
| AUTHORS： | WANG Huihong，HUANG He，REN Yiqiang |
| 关键字： | 参松养心胶囊；胺碘酮；室性心律失常；心率；疗效；安全性 |
| KEYWORDS： | Shensong yangxin capsule； Amiodarone； Ventricular tachyarrhythmia； Heart rate； Therapeutic efficacy； Safety |
| 阅读数： | 519 次 |
| 本月下载数： | 3 次 |
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