甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响
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篇名: 甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响
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摘要: 目的:探讨甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响。方法: 150例甲状腺功能亢进症患者随机分为A组(50例)、B组(50例)和C组(50例)。在常规治疗的基础上,A组患者给予甲巯咪唑片起始剂量20~40 mg,口服,每日1~2次,连用2~6周后若病情改善,则减量至2.5~10 mg并维持,若无改善则维持20~40 mg;B组患者给予穴位敷贴治疗贴1贴,每日早餐后1 h贴于足三里、三阴交、神门、太冲、内关等穴位处。C组患者给予甲巯咪唑片(用法用量同A组)+穴位敷贴治疗贴(用法用量同B组)。3组疗程均为2个月。观察3组患者治疗前后促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、睾酮(T)、雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、血清降钙素(CT)、骨钙素(BGP)、甲状旁腺素(PTH)水平及不良反应发生情况。结果:治疗前,3组患者上述指标比较,差异均无统计学意义(P>0.05)。治疗后,3组患者TSH、PTH水平均显著高于同组治疗前,且C组显著高于A、B组;3组患者FT3、FT4、T3、T4、T、E2、LH、FSH、CT、BGP水平均显著低于同组治疗前,且C组显著低于A、B组,差异均有统计学意义(P<0.05);但各项指标A、B组间比较,差异均无统计学意义(P>0.05)。3组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,甲巯咪唑联合穴位敷贴治疗贴可显著改善甲亢患者的甲状腺功能,性激素水平紊乱和骨代谢异常,且未增加不良反应的发生。
ABSTRACT: OBJECTIVE: To investigate the effects of methimazole combined with acupoint application on hormone levels and bone metabolism indexes of patients with hyperthyroidism. METHODS: 150 hyperthyroidism patients were randomly divided into group A (50 cases), group B (50 cases) and group C (50 cases). Based on routine treatment, group A was given Methimazole tablets orally, with initial dose of 20-40 mg, 1-2 times a day; 2-6 weeks later, reducing and maintaining at 2.5-10 mg if the disease condition was improved; maintaining 20-40 mg if no improvement. Group B was acupoint application, one piece, pasting on Zusanli, Sanyinjiao, Shenmen, Taichong, Neiguan points 1 h after breakfast. Group C received Methimazole tablets (same usage and dosage as group A)+acupoint application (same usage and dosage as group B). Treatment courses of 3 groups lasted for 2 months. The levels of TSH, FT3, FT4, T3, T4, T, E2, LH, FSH, CT, BGP and PTH were observed in 3 groups before and after treatment, and the occurrence of ADR was also observed. RESULTS: Before treatment, there was no statistical significance in the levels of above indexes among 3 groups (P>0.05). After treatment, the levels of TSH and PTH in 3 groups were significantly higher than before, and the group C was significantly higher than the group A and B. The levels of FT3, FT4, T3, T4, T, E2, LH, FSH, CT and BGP in 2 groups were significantly lower than before, and the group C was significantly lower than the group A and B; there was statistical significance (P<0.05). There was no statistical significance in each index between group A and B (P>0.05). There was no statistical significance in the incidence of ADR among 3 groups (P>0.05). CONCLUSIONS: Based on routine treatment, methimazole combined with acupoint application can significantly improve the thyroid function, correct the disorder of sex hormones and abnormal bone metabolism in hyperthyroidism patient, without increasing the incidence of ADR.
期刊: 2017年第28卷第21期
作者: 景良洪,陈琼科#,宋凤萍,曾艳丽
AUTHORS: JING Lianghong,CHEN Qiongke,SONG Fengping,ZENG Yanli
关键字: 甲状腺功能亢进症;甲巯咪唑;穴位敷贴治疗贴;甲状腺激素;性激素;骨代谢;安全性
KEYWORDS: Hyperthyroidism; Methimazole; Acupoint application; Thyroid hormone; Sex hormone; Bone metabolism; Safety?
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