1例AECOPD并发变应性支气管肺曲霉菌病的药学监护
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篇名: | 1例AECOPD并发变应性支气管肺曲霉菌病的药学监护 |
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摘要: | 目的:探讨临床药师在慢性阻塞性肺疾病急性加重期(AECOPD)并发变应性支气管肺曲霉菌病(ABPA)患者药物治疗中的作用。方法:临床药师参与1例AECOPD合并ABPA患者的药物治疗,根据患者病情,临床药师建议调整初始治疗方案中沙丁胺醇和布地奈德雾化吸入顺序;治疗过程中停用头孢曲松,调整为静脉滴注伏立康唑;之后适时调整伏立康唑为口服剂型,并对整个治疗过程进行监测,密切关注药物的治疗效果以及出现的不良反应,对患者进行用药教育。结果:医师采纳临床药师建议,及时调整雾化剂吸入顺序和伏立康唑的用药剂量及给药途径,患者病情明显好转,出院后继续药物治疗。结论:临床药师全程参与患者治疗提高了治疗效果、减少了不良反应的发生,促进了临床合理用药。 |
ABSTRACT: | OBJECTIVE: To explore the role of clinical pharmacists in the therapy for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with allergic bronchopulmonary aspergillosis (ABPA). METHODS: Clinical pharmacists participated in the therapy for a AECOPD patient with ABPA. According to patient’s condition, clinical pharmacists suggested adjusting the inhalation order of salbutamol and budesonide aerosol inhalation; stopping cefatriaxone and adjusting to intravenous injection of voriconazole; and then adjusting voriconazole to oral dosage form timely, monitoring therapy duration. Clinical pharmacists paid close attention to therapeutic efficacy and ADR, and provided medication education for patients. RESULTS: Physicians adopted the suggestion of clinical pharmacists to adjust inhalation order of aerosols, the dosage and route of administration of voriconazole. The patient’s condition was improved obviously, and the drug therapy was continued after discharge. CONCLUSIONS: Clinical pharmacists participating in the whole process of treatment improves therapeutic efficacy, reduces the occurrence of ADR and promotes rational drug use in clinic. |
期刊: | 2017年第28卷第20期 |
作者: | 于静,周霞瑾,杨继章 |
AUTHORS: | YU Jing,ZHOU Xiajin,YANG Jizhang |
关键字: | 慢性阻塞性肺疾病急性加重期;变应性支气管肺曲霉菌病;药学监护;合理用药 |
KEYWORDS: | Acute exacerbation of chronic obstructive pulmonary disease; Allergic bronchopulmonary aspergillosis;Pharmaceutical care; Rational drug use |
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