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疏血通注射液联合前列地尔治疗急性脑梗死的临床观察
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| 篇名： | 疏血通注射液联合前列地尔治疗急性脑梗死的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察疏血通注射液联合前列地尔治疗急性脑梗死（ACI）的临床疗效及安全性。方法：选取2014年3月－2016年9月我院收治的ACI患者123例作为研究对象，按照随机数字表法分为观察组（62例）和对照组（61例）。对照组患者在常规治疗基础上给予前列地尔注射液2 mL+0.9％氯化钠注射液100 mL，ivgtt，qd；观察组患者在对照组基础上给予疏血通注射液6 mL+0.9％氯化钠注射液250 mL，ivgtt，qd。两组疗程均为2周。比较两组患者治疗前后的血小板平均体积（MPV）、纤维蛋白原（FIB）含量、血液流变学指标、神经功能缺损程度评分，以及临床疗效和不良反应发生情况。结果：治疗前，两组患者的MPV和FIB含量、血液流变学指标及神经功能缺损程度评分比较，差异均无统计学意义（P＞0.05）；与治疗前比较，治疗后两组患者的MPV显著减小，FIB含量、血液流变学指标及改良Rankin量表（mRS）评分均显著降低，巴塞尔指数（BI）和美国国立卫生研究院卒中量表（NIHSS）评分均显著升高，且观察组的各项结果均优于对照组，差异均有统计学意义（P＜0.05）。观察组患者的总有效率为95.16％，显著高于对照组的85.25％，差异有统计学意义（P＜0.05）。两组患者均未见严重不良反应发生。结论：疏血通注射液联合前列地尔可显著改善ACI患者神经功能缺损程度，并通过降低MPV和FIB含量来改善患者血液高凝状态，疗效较好，且安全性高。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Shuxuetong injection combined with alprostadil in the treatment of acute cerebral infraction （ACI）. METHODS： A total of 123 ACI patients selected from our hospital during Mar. 2014-Sept. 2016 selected as research subjects were divided into observation group （62 cases） and control group （61 cases） according to random number table. Control group was additionally given Alprostadil injection 2 mL+0.9％ Sodium chloride injection 100 mL， ivgtt， qd， on the basis of routine treatment. Observation group was additionally given Shuxuetong injection 6 mL+0.9％ Sodium chloride injection 250 mL， ivgtt， qd， on the basis of control group. Both groups were treated for 2 weeks. MPV， FIB content， hemorheology indexes， neurologic impairment degree score before and after treatment as well as clinical efficacy， the occurrence of ADR were compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in MPV， FIB content， hemorheology indexes or neurologic impairment score between 2 groups （P＞0.05）. Compared with before treatment， MPV， FIB content， hemorheology indexes and modified Rankin scale of 2 groups were all decreased significantly； Barthel index and NIHSS scores were increased significantly， and each aspect of observation group was better than that of control group， with statistical significance （P＜0.05）. Total response rate of observation group was 95.16％， which was significantly higher than 85.25％ of control group， with statistical significance （P＜0.05）. No severe ADR was found in 2 groups. CONCLUSIONS： Shuxuetong injection combined with alprostadil can significantly improve the neurological function of ACI patients， improve hypercoagulable state by reducing MPV and FIB content， and have good therapeutic efficacy and safety. |
| 期刊： | 2017年第28卷第20期 |
| 作者： | 程伟宁，李小林，黄龙虎，朱静，罗旺胜，宋郁喜 |
| AUTHORS： | CHENG Weining，LI Xiaolin，HUANG Longhu，ZHU Jing，LUO Wangsheng，SONG Yuxi |
| 关键字： | 程伟宁，李小林，黄龙虎，朱静，罗旺胜，宋郁喜 |
| KEYWORDS： | CHENG Weining，LI Xiaolin，HUANG Longhu，ZHU Jing，LUO Wangsheng，SONG Yuxi |
| 阅读数： | 672 次 |
| 本月下载数： | 4 次 |
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