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静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床观察
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| 篇名： | 静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨静脉滴注前列地尔结合针灸治疗糖尿病足溃疡的临床疗效，及对患者炎症因子水平及创面微血管密度的影响。方法：选取2014年5月－2015年9月我院收治的糖尿病足溃疡患者72例，按随机数字表法分为观察组和对照组，各36例。对照组患者在给予胰岛素等基础治疗上应用前列地尔注射液10 μg加入250 mL 0.9％氯化钠注射液中静脉滴注，qd；观察组患者在对照组基础上加针灸治疗（三阴交、足三里、丰隆、阳陵泉、阴陵泉等穴位），qd。两组疗程均为3周。比较两组患者的临床疗效、创面愈合时间、空腹血糖、尿微量白蛋白水平、炎症因子水平、创面微血管密度和不良反应发生情况。结果：观察组患者的总有效率（91.67％）显著高于对照组（72.22％），创面愈合时间显著短于对照组，差异均有统计学意义（P＜0.05）。 治疗前，两组患者的空腹血糖、尿微量白蛋白和各炎症因子水平比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者的上述指标水平均显著低于治疗前，且观察组的尿微量白蛋白和各炎症因子水平显著低于对照组，差异均有统计学意义（P＜0.05）。治疗14、21 d后，观察组患者的创面微血管密度均显著高于同期对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：静脉滴注前列地尔结合针灸可通过减轻炎症反应、促进微血管生成，缩短糖尿病足溃疡患者的创面愈合时间，增强其疗效。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy of intravenous drip of alprostadil combined with acupuncture in the treatment of diabetic foot ulcer and its effects on inflammatory factors levels and wound microvascular density. METHODS： A total of 72 patients with diabetic foot ulcer in our hospital during May 2014 to Sept. 2015 were divided into observation group and control group according to random number table， with 36 cases in each group. Control group was given Alprostadil injection 10 μg added into 250 mL 0.9％ Sodium chloride injection intravenously， qd， on the basis of routine treatment as insulin. Observation group was additionally given acupuncture therapy （Sanyinjiao， Zusanli， Fenglong， Yanglingquan， Yinlingquan and other acupuncture points）， qd， on the basis of control group. Treatment courses of 2 groups lasted for 3 weeks. Clinical efficacy， wound healing time， fasting blood glucose， urine microalbumin， inflammatory factors， wound microvascular density as well as the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （91.67％） was significantly higher than that of control group （72.22％）， and wound healing time was significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in fasting blood glucose， urine microalbumin and inflammatory factors between 2 groups （P＞0.05）. After treatment， above indexes of 2 groups were significantly lower than before， and urine microalbumin and inflammatory factors of the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. 14， 21 d after treatment， wound microvessel density of observation group was significantly higher those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Intravenous drip of Alprostadil combined with acupuncture can boost angiogenesis through mitigating inflammatory reactions， thus shorten the time of wound healing and enhance therapeutic efficacy. |
| 期刊： | 2017年第28卷第20期 |
| 作者： | 邵礼成，严文，李赞钊，黄文柱 |
| AUTHORS： | SHAO Licheng，YAN Wen，LI Zanzhao，HUANG Wenzhu |
| 关键字： | 前列地尔；针灸；糖尿病足；溃疡；微血管密度；微循环障碍；炎症因子 |
| KEYWORDS： | Alprostadil； Acupuncture； Diabetic foot； Ulcer； Microvascular density； Microcirculatory disturbance； Inflammatory factor |
| 阅读数： | 294 次 |
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