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麻黄附子细辛汤抗过敏性鼻炎有效组分的组方研究
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| 篇名： | 麻黄附子细辛汤抗过敏性鼻炎有效组分的组方研究 |
| TITLE： | |
| 摘要： | 目的：研究抗过敏性鼻炎（AR）中药有效组分的新组方，为抗AR现代中药制剂的开发提供参考。方法：以麻黄附子细辛汤中盐酸伪麻黄碱（0～13.5 mg/kg）、附子总碱提取物（0～21.18 mg/kg）和细辛挥发油（0～0.009 2 mL/kg）为组方对象，采用均匀设计法进行分组给药，对AR豚鼠给药前后行为学积分、血清中组胺和免疫球蛋白E（IgE）的含量进行多元回归分析，以获得最佳组方。分别以辛芩颗粒、氯雷他定片和麻黄附子细辛汤为阳性对照，以AR豚鼠给药前后行为学积分、血清中组胺和IgE含量对最佳组方的药效进行验证；并通过小鼠急性毒性实验初步观察最佳组方的安全性。结果：最佳组方为盐酸伪麻黄碱11.25 mg/kg、附子总碱提取物21.18 mg/kg、细辛挥发油0.004 5 mL/kg。最佳组方组豚鼠给药前后行为学积分与各阳性药物组比较均无统计学差异（P＞0.05），血清中组胺含量较辛芩颗粒组和麻黄附子细辛组显著降低（P＜0.05），血清中IgE含量较辛芩颗粒和氯雷他定片组显著降低（P＜0.05）。最佳组方的半数致死量为1 822.04 mg/kg。结论：本研究筛选的最佳组方在减少血清中组胺含量方面较辛芩颗粒和麻黄附子细辛汤效果更佳，在减少血清中IgE含量方面较氯雷他定片和辛芩颗粒效果更佳，且安全性较好，在一定程度上说明了中药有效成分组方的可行性。 |
| ABSTRACT： | OBJECTIVE： To study the new formula of effective components in TCM for anti-allergic rhinitis （AR）， and provide reference for developing TCM preparations for anti-AR. METHODS： Using pseudoephedrine hydrochloride （0-13.5 mg/kg）， total alkaloid extracts of Aconitum carmichaelii （0-21.18 mg/kg）， volatile oil of asari radix （0-0.009 2 mL/kg） in Mahuang Fuzi Xixin decoction as formula objects， uniform design method was used for drug grouping， and multiple regression analysis was conducted for the behavioral scores before and after administration， contents of histamine and immunoglobulin E （IgE） in serum of AR guinea pigs to obtain the best formula. Using Xinqin granule， Loratadine tablet， Mahuang Fuzi Xixin decoction respectively as positive control， efficacy of the best formula was verified from aspects of behavioral scores before and after administration， contents of histamine and IgE of AR guinea pigs. And the safety of the best formula was preliminarily observed through acute toxicity test in mice. RESULTS： The best formula was as follow as pseudoephedrine hydrochloride 11.25 mg/kg， total alkaloid extracts of A. carmichaelii 21.18 mg/kg， volatile oil of asari radix 0.004 5 mL/kg. Compared with each positive drug group， there were no significant differences in behavioral scores before and after administration in the best formula group （P＞0.05）. While compared with Xinqin granule group and Mahuang Fuzi Xixin decoction group， histamine content in serum in the best formula group was significantly reduced （P＜0.05）； compared with Xinqin granule and Loratadine tablet group， IgE content in serum in the best formula group was significant decreased （P＜0.05）. Median lethal dose of the best formula was 1 822.04 mg/kg. CONCLUSIONS： The screened best formula shows better effect than Xinqin granule and Mahuang Fuzi Xixin decoction in terms of reducing histamine content in serum， better than Loratadine tablet and Xinqin granule in terms of reducing IgE content in serum， with good safety， which indicates the feasibility of TCM effective component formula to a certain degree. |
| 期刊： | 2017年第28卷第19期 |
| 作者： | 黄瑶，师大智，谭晓梅，黄茵茵，夏曼丽 |
| AUTHORS： | HUANG Yao，SHI Dazhi，TAN Xiaomei，HUANG Yinyin，XIA Manli |
| 关键字： | 麻黄附子细辛汤；均匀设计；盐酸伪麻黄碱；附子总碱提取物；细辛挥发油；过敏性鼻炎；豚鼠 |
| KEYWORDS： | Mahuang Fuzi Xixin decoction； Uniform design； Pseudoephedrine hydrochloride； Total alkaloid extracts of Aconitum carmichaelii； Volatile?oil?of?asari radix； Allergic rhinitis； Guinea pigs |
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