低分子肝素钠联合地屈孕酮治疗先兆流产的临床观察
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篇名: 低分子肝素钠联合地屈孕酮治疗先兆流产的临床观察
TITLE:
摘要: 目的:观察低分子肝素钠联合地屈孕酮治疗先兆流产的疗效和安全性。方法:回顾性分析72例先兆流产妊娠期妇女资料,按用药的不同分为对照组(36例)和观察组(36例)。对照组妊娠期妇女口服地屈孕酮片起始剂量40 mg,1日后每12 h 1次,每次10 mg。观察组妊娠期妇女在对照组治疗的基础给予低分子肝素钠注射液5 000 U,腹壁皮下注射,每日1次。两组均用药1周。观察两组妊娠期妇女的临床疗效,腰酸、阴道流血、腹痛时间及总治疗时间,新生儿出生体质量、妊娠期妇女分娩时妊娠天数,治疗前后超敏C反应蛋白(hs-CRP)、纤维蛋白原、D-二聚体、血小板水平及不良反应发生情况。结果:观察组妊娠期妇女总有效率显著高于对照组(91.7% vs. 80.6%),腰酸、阴道流血、腹痛时间及总治疗时间均显著短于对照组,新生儿出生体质量、妊娠期妇女分娩时妊娠天数均显著多于对照组,差异均有统计学意义(P<0.05)。治疗前,两组妊娠期妇女hs-CRP、纤维蛋白原、D-二聚体、血小板水平比较,差异均无统计学意义(P>0.05);治疗后,两组妊娠期妇女hs-CRP、纤维蛋白原、D-二聚体、血小板水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组妊娠期妇女不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,低分子肝素钠联合地屈孕酮治疗先兆流产的疗效和安全性均较好。
ABSTRACT: OBJECTIVE: To observe therapeutic efficacy and safety of low-molecular-weight-heparin-sodium combined with dydrogesterone in the treatment of threatened abortion. METHODS: Medical information of 72 patients with threatened abortion were analyzed retrospectively and divided into control group (36 cases) and observation group (36 cases). Control group was given Dydrogesterone tablet with initial dose of 40 mg, one day later every 12 h 10 mg/time. Observation group was additionally given abdominal subcutaneous injection of Low-molecular-weight-heparin-sodium injection 5 000 U, once a day, on the basis of control group. Both groups were treated for a week. Clinical efficacies of 2 groups were observed, and lumbar acid, vaginal bleeding, abdominal pain time, total treatment time, neonatal birth weight were also observed. The levels of hs-CRP, fibrinogen, D-dimer and platelet, the occurrence of ADR were observed before and after treatment. RESULTS: The total response rate of observation group was significantly higher than that of control group(91.7% vs. 80.6%), the backache, vaginal bleeding, abdominal pain time and total treatment time of observation group were significantly shorter than those of control group, the neonatal birth weight and gestational age of observation group were significantly more than those of control group, with statistical significance (P<0.05). Before treatment,there was no statistical significance in the levels of hs-CRP,fibrinogen,D-dimer and platelet between 2 group(P>0.05); after treatment, the levels of hs-CRP, fibrinogen, D-dimer and platelet in 2 groups were significantly lower than before, and the observation group was significantly lower than the control group, with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS: Based on routine treatment, low-molecular-weight-heparin-sodium combined with dydrogesterone shows good therapeutic efficacy and safety for threatened abortion.
期刊: 2017年第28卷第18期
作者: 李慧,吴小妹,周玉华
AUTHORS: LI Hui,WU Xiaomei,ZHOU Yuhua
关键字: 低分子肝素钠;地屈孕酮;先兆流产;疗效;安全性
KEYWORDS: Low-molecular-weight-heparin-sodium; Dydrogesterone; Threatened abortion; Therapeutic efficacy; Safety
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