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辛夷鼻炎丸联合布地奈德治疗变应性鼻炎的疗效及其对相关炎症因子的影响
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| 篇名： | 辛夷鼻炎丸联合布地奈德治疗变应性鼻炎的疗效及其对相关炎症因子的影响 |
| TITLE： | |
| 摘要： | 目的：观察辛夷鼻炎丸联合布地奈德治疗变应性鼻炎的疗效及其对相关炎症因子的影响。方法： 120例变应性鼻炎患者随机分为观察组和对照组，每组60例。对照组患者给予布地奈德鼻喷雾剂治疗，1个鼻孔喷1次（64 μg/喷），每天2次。观察组患者在对照组治疗基础上加服辛夷鼻炎丸3 g， 每日3次。两组疗程均为4周。观察并比较两组患者临床疗效，治疗前后临床症状和体征总积分变化情况，血清免疫球蛋白E（IgE）和白细胞三烯E4（LTE4）含量，同时记录不良反应发生情况。结果：观察组和对照组分别有3、4例患者脱落。观察组患者总有效率显著高于对照组，差异有统计学意义（84.21％ vs. 73.21％，P＜0.05）。治疗前，两组患者临床症状和体征总积分、IgE和LTE4水平比较，差异无统计学意义（P＞0.05）；治疗2、4周后，两组患者临床症状和体征总积分、IgE 和LTE4水平显著低于同组治疗前，且观察组显著低于同期对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：辛夷鼻炎丸联合布地奈德治疗变应性鼻炎疗效较好，可以显著改善患者临床症状和体征，降低炎症因子水平，安全性亦较好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy of Xinyi biyan pills combined with budilaide in the treatment of allergic rhinitis and its effects on related inflammatory factors. METHODS： A total od 120 patients with allergic rhinitis were randomly divided into observation group and control group， with 60 cases in each group. Control group was treated with Budesonide nasal spray， spraying once each nostril（64 μg/spray）， 2 times a day. Observation group was additionally treated with Xinyi biyan pills 3 g， 3 times a day. Treatment course lasted for 4 weeks. Clinical efficacies of 2 groups were observed and compared. The changes of total score of clinical symptoms and signs were observed before and after treatment. The contents of IgE and LTE4 were determined， and the occurrence of ADR was recorded. RESULTS： Three patients of observation group and 4 patients of control group fell of the study. Total response rate of observation group was significantly higher than that of control group， with statistical significance （84.21％ vs. 73.21％，P＜0.05）. Before treatment， there was no statistical significance in total score of clinical symptoms and signs， IgE and LTE4 levels between 2 groups （P＞0.05）. After 2 and 4 weeks of treatment， total score of clinical symptoms and signs， IgE and LTE4 levels in 2 groups were significantly lower than before treatment， and the observation group was significantly lower than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Xinyi biyan pills combined with budesonide show good therapeutic efficacy for allergic rhinitis， improve clinical symptoms and signs significantly and reduce inflammatory factors levels with good safety. |
| 期刊： | 2017年第28卷第18期 |
| 作者： | 晋舒，宋敏 |
| AUTHORS： | JIN Shu，SONG Min |
| 关键字： | 辛夷鼻炎丸；布地奈德；变应性鼻炎；临床疗效；安全性 |
| KEYWORDS： | Xinyi biyan pills； Budesonide； Allergic rhinitis； Clinical efficacy； Safety |
| 阅读数： | 365 次 |
| 本月下载数： | 4 次 |
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