低分子肝素与利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓的有效性和安全性比较
x

请在关注微信后,向客服人员索取文件

篇名: 低分子肝素与利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓的有效性和安全性比较
TITLE:
摘要: 目的:比较低分子肝素、利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓(DVT)的有效性和安全性。方法:58例行髋关节或人工股骨头置换术的老年患者随机分为低分子肝素组(29例)和利伐沙班组(29例)。所有患者术后均给予基本治疗及物理预防DVT;在此基础上,利伐沙班组患者术后10 h开始口服利伐沙班片10 mg,每日1次,连用10 d;低分子肝素组患者术后10 h给予低分子肝素钙注射液4 100 IU,皮下注射,每日1次,连用10 d。观察两组患者术后DVT发生情况,D-二聚体阳性发生情况,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)及血小板计数异常发生情况。结果:两组患者DVT发生率,术后4、10 d两组患者D-二聚体阳性发生情况,PT、APTT、TT、FIB及血小板计数异常发生情况比较,差异均无统计学意义(P>0.05)。结论:低分子肝素、利伐沙班均可用于预防老年患者骨折置换术后双下肢DVT,且其疗效和安全性均相当。
ABSTRACT:

OBJECTIVE: To compare the effectiveness and safety of low-molecular-weight-heparin (LMWH) calcium and rivaroxaban in preventing lower extremity deep venous thrombosis (DVT) in the elderly patients after surgery of replacement of fracture. METHODS: A total of 58 elderly patients underwent hip or artificial femoral head replacement were randomly divided into LMWH group (29 cases) and Rivaroxaban group (29 cases). All patients received basic prevention and physical prevention for DVT after surgery. Based on this, LMWH group was given Heparin calcium injection 4 100 IU subcutaneously 10 h after surgery, for 10 d. Rivaroxabar group was given Rivaroxaban tablet 10 mg 10 h after surgery, once a day, for consecutive 10 d. The occurrence of DVT and positive D-dimer were observed in 2 groups after surgery. The PT, APTT, TT, FIB and platelet counts abnormality were also observed in 2 groups. RESULTS: There was no statistical significance in the incidence of DVT, the occarrence of positive D-dimer, PT, APTT, TT, FIB and platelet counts abnormality 4, 10 d after surgery between 2 groups(P>0.05). CONCLUSIONS: LMWH and rivaroxaban both can be used for lower extremity DVT in the elderly patients after replacement of fracture surgery of and have similar therapeutic efficacy and safety.


期刊: 2017年第28卷第18期
作者: 陆惠平,刘彦儒,高培培,龚婧如
AUTHORS: LU Huiping,LIU Yanru,GAO Peipei,GONG Jingru
关键字: 低分子肝素;利伐沙班;深静脉血栓;骨折置换术;疗效;安全性
KEYWORDS: Low-molecular-weight-heparin; Rivaroxaban; Deep vein thrombosis; Surgery of replacement of fracture; Therapeutic efficacy; Safety
阅读数: 1139 次
本月下载数: 9 次

* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!