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苁蓉益肾颗粒联合盐酸多奈哌齐片治疗帕金森病痴呆的临床研究
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| 篇名： | 苁蓉益肾颗粒联合盐酸多奈哌齐片治疗帕金森病痴呆的临床研究 |
| TITLE： | |
| 摘要： | 目的：观察苁蓉益肾颗粒联合盐酸多奈哌齐片对帕金森病痴呆（PDD）患者精神状态、生活质量的影响及安全性。方法：将60例PDD患者按随机数字表法分为对照组和治疗组，各30例。两组患者均服用治疗帕金森病的药物，对照组患者在此基础上口服盐酸多奈哌齐片5 mg，qd；治疗组患者在对照组基础上加服苁蓉益肾颗粒2 g，bid。两组疗程均为6个月。观察两组患者治疗前后简易智能量表（MMSE）、蒙特利尔认知评估量表（MoCA）、日常生活活动量表（ADL-R）认知部分（ADAS-Cog）、ADL-R评分和中医症状积分，并比较两组患者不良反应发生情况。结果：治疗前，两组患者MMSE、MoCA、ADAS-Cog、ADL-R评分和中医症状积分比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者MMSE、MoCA评分均显著升高，ADAS-Cog、ADL-R评分和中医症状积分均显著降低，且治疗组评分显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：苁蓉益肾颗粒联合盐酸多奈哌齐片能明显改善PDD患者精神状态和认知能力，缓解临床症状，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To observe the effects and safety of Congrong yishen granule combined with Donepezil hydrochloride tablet on mental state and quality of life in patients with Parkinson disease with dementia （PDD）. METHODS： A total of 60 PDD patients were randomized into control group and treatment group， with 30 cases in each group. Both groups were given drugs for Parkinson disease. Control group was additionally given Donepezil hydrochloride tablet 5 mg， qd； treatment group was additionally given Congrong yishen granules 2 g， bid， on the basis of control group. The treatment lasted for 6 months in both groups. MMSE， MoCA， ADAS-Cog， ADL-R and TCM symptom score were observed in 2 groups before and after treatment. The occurrence of ADR were compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in MMSE， MoCA， ADAS-Cog， ADL-R or TCM symptom score between 2 groups （P＞0.05）. After treatment， MMSE and MoCA score of 2 groups were increased significantly， while ADAS-Cog， ADL-R and TCM symptom score were decreased significantly； the treatment group were better than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Congrong yishen granule combined with donepezil hydrochloride tablet can significantly improve mental state and cognitive ability of PDD patients， and relieve clinical symptoms with good safety. |
| 期刊： | 2017年第28卷第17期 |
| 作者： | 顾超，沈婷，袁灿兴，安红梅，顾婷婷，张田丽 |
| AUTHORS： | GU Chao，SHEN Ting，YUAN Canxing，AN Hongmei，GU Tingting，ZHANG Tianli |
| 关键字： | 帕金森病痴呆；苁蓉益肾颗粒；精神状态；认知能力；盐酸多奈哌齐片 |
| KEYWORDS： | Parkinson disease with dementia； Congrong yishen granule； Mental state； Cognitive ability； Donepezil hydrochloride tablet |
| 阅读数： | 389 次 |
| 本月下载数： | 5 次 |
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