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氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性变应性鼻炎的临床研究
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| 篇名： | 氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性变应性鼻炎的临床研究 |
| TITLE： | |
| 摘要： | 目的：探讨氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性变应性鼻炎（AR）的临床效果及安全性。方法：选取河北医科大学第二医院2013年1月－2015年6月收治的间歇性AR患者共300例，按抽签法分为A、B、C组，各100例。A组患者给予氯雷他定片10 mg，po，qd；B组患者采用生理性海水鼻腔喷雾器进行鼻腔冲洗，早晚各冲洗1次；C组患者给予氯雷他定口服联合生理性海水鼻腔冲洗。3组患者疗程均为28 d。比较3组患者的临床疗效，治疗前后症状体征积分、呼吸功能指标和炎症因子指标水平，以及随访12个月期间的临床复发情况。结果：A、B、C组患者的总有效率分别为80.00％、78.00％、96.00％，C组显著高于A、B组，差异均有统计学意义（P＜0.05）。治疗前，3组患者的症状体征积分、呼吸功能指标和炎症因子水平比较，差异均无统计学意义（P＞0.05）；治疗后，3组患者的症状体征积分、最大呼气流速（PEF）昼夜变异率、肿瘤坏死因子α、γ干扰素和白细胞介素（IL）-4水平均显著低于治疗前，PEF和IL-12水平均显著高于治疗前，且C组患者各指标水平均显著优于A、B组，差异均有统计学意义（P＜0.05）。A、B、C组患者的临床复发率分别为21.00％、23.00％、6.00％，C组显著低于A、B组，差异均有统计学意义（P＜0.05）。A、B组患者上述所有指标比较，差异均无统计学意义（P＞0.05）。结论：氯雷他定口服联合生理性海水鼻腔冲洗治疗间歇性AR可有效减轻患者鼻部症状体征，改善患者呼气功能，下调机体炎症反应水平，并有助于降低远期复发风险。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy and safety of oral loratadine combined with physiological seawater nasal irrigation in the treatment of intermittent allergic rhinitis. METHODS： Totally 300 patients with intermittent allergic rhinitis were chosen from the Second Hospital of Hebei Medical University during Jan. 2013-Jun. 2015， and then divided into group A， B， C according to lottery method， with 100 cases in each group. Group A was given Loratadine tablets 10 mg， po， qd. Group B received nasal irrigation with physiological seawater nasal spray， every morning and evening. Group C was given oral loratadine combined with physiological seawater nasal irrigation. Treatment courses of 3 groups lasted for 28 d. Clinical efficiencies of 3 groups were compared as well as symptom and sign scores， respiration function indexes and inflammatory factor levels before and after treatment， and the clinical recurrences were followed up for 12 months. RESULTS： The total response rates of group A， B， C were 80.00％， 78.00％， 96.00％， respectively， and that of group C was significantly higher than that of group A and B， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in symptom and sign scores， respiration function indexes and inflammatory factor levels among 3 groups （P＞0.05）. After treatment， symptom and sign scores， the rates of PEF diurnal variation， TNF-α， INF-γ and IL-4 in 3 groups were significantly lower than before treatment， and the levels of PEF and IL-12 were significantly higher than before treatment. Above indexes of group C were significantly better than those of group A and B， with statistical significance （P＜0.05）. Clinical recurrence rates of group A， B， C were 21.00％， 23.00％， 6.00％， and group C was significantly lower than the group A and B， with statistical significance （P＜0.05）. There was no statistical significance in above indexes between group A and group B （P＞0.05）. CONCLUSIONS： Oral loratadine combined with physiological seawater nasal irrigation in treatment of intermittent allergic rhinitis can efficiently relieve the nasal symptoms and signs， improve expiratory function， reduce the inflammatory response levels and be helpful to reduce the long-term recurrence risk. |
| 期刊： | 2017年第28卷第14期 |
| 作者： | 毛昳楠，张燕，段乃超，?杨彦忠，蔡丽，胡晓敏，李云，张学梅 |
| AUTHORS： | MAO Yinan，ZHANG Yan，DUAN Naichao，YANG Yanzhong，CAI Li，HU Xiaomin，LI Yun，ZHANG Xuemei |
| 关键字： | 氯雷他定；生理性海水；间歇性变应性鼻炎；炎症反应 |
| KEYWORDS： | Loratadine； Physiological seawater； Intermittent allergic rhinitis； Inflammatory response |
| 阅读数： | 471 次 |
| 本月下载数： | 2 次 |
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