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丹参酮联合角膜缘干细胞移植术治疗翼状胬肉的临床观察
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| 篇名： | 丹参酮联合角膜缘干细胞移植术治疗翼状胬肉的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察丹参酮联合角膜缘干细胞移植术治疗翼状胬肉的临床疗效和安全性。方法：采用回顾性分析方法，选取我院2010年2月－2014年9月收治的原发性翼状胬肉患者97例（118眼），根据用药情况分为观察组48例（57眼）和对照组49例（61眼）。两组患者均行自体角膜缘干细胞移植术。对照组患者于术前1周开始给予妥布霉素地塞米松滴眼液1～2滴，每4～6 h 1次，行常规治疗；观察组患者在对照组基础上给予丹参酮胶囊0.5 g，po，tid，连用3个月。比较两组患者角膜上皮修复时间和局部症状消退时间，观察两组患者术前及术后1、3个月角膜散光度和矫正视力情况，并统计两组患者复发和不良反应发生情况。结果：观察组患者角膜上皮修复时间、局部症状消退时间均显著短于对照组，差异有统计学意义 （P＜0.05）。两组患者术前及术后1个月角膜散光、矫正视力比较，差异无统计学意义（P＞0.05）；与术前比较，术后1、3个月两组患者角膜散光度显著降低、矫正视力显著升高，且术后3个月观察组显著优于对照组，差异均有统计学意义（P＜0.05）。观察组患者复发率为3.51％，显著低于对照组的14.75％，差异有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：丹参酮联合自体角膜缘干细胞移植术治疗翼状胬肉，能显著缩短角膜上皮修复和局部症状消退时间，恢复患者视功能，降低复发率，且安全性好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of tanshinone combined with limbal stem cells transplantation in the treatment of pterygium. METHODS： Totally 97 cases （118 eyes） of primary pterygium admitted into our hospital during Feb. 2010-Sept. 2014 were analyzed retrospectively， and divided into observation group （48 cases， 57 eyes） and control group （49 cases， 61 eyes）. Both groups received autologous limbal stem cell transplantation. The control began to give Tobramycin and dexamethasone eye drops 1-2 drop 1 week before surgery， every 4-6 h one times. Observation group was given Tanshinone capsules 0.5 g， po， tid， one week before surgery， for 3 months. Repair time of corneal epithelium and local symptom regression time were compared between 2 groups. Corneal astigmatism and corrected visual acuity were observed in 2 groups before and 1， 3 months after surgery. The occurrence of recurrence and ADR was analyzed statistically in 2 groups. RESULTS： The repairing time of corneal pithelial and local symptom regression time in observation group were significantly shorter than control group， with statistical significance （P＜0.05）. There was no statistical significance in corneal astigmatism and corrected visual acuity between 2 groups before and one month after surgery （P＞0.05）. 1， 3 months after surgery， corneal astigmatism of 2 groups was decreased significantly and corrected visual acuity was increased significantly than before surgery， and 3 months after surgery the observation group was significantly better than the control group， with statistical significance （P＜0.05）. The recurrence rate of observation group was 3.51％， which was significantly lower than 14.75％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Tanshinone combined with autologous limbal stem cell transplantation in the treatment of pterygium can shorten the time of corneal epithelial repair and local symptoms， restore the visual function of patients and reduce recurrence rate with good safety. |
| 期刊： | 2017年第28卷第14期 |
| 作者： | 桂平，胡雪芬，张婵娟，费颐，谈伟 |
| AUTHORS： | GUI Ping，HU Xuefen，ZHANG Chanjuan，FEI Yi，TAN Wei |
| 关键字： | 丹参酮；翼状胬肉；自体角膜缘干细胞移植术；复发率；视功能 |
| KEYWORDS： | Tanshinone； Pterygium； Autologous limbal stem cell transplantation； Recurrence rate； Visual function |
| 阅读数： | 266 次 |
| 本月下载数： | 2 次 |
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