利多卡因硬膜外阻滞复合全麻对肺癌患者术后相关指标的影响
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篇名: 利多卡因硬膜外阻滞复合全麻对肺癌患者术后相关指标的影响
TITLE:
摘要: 目的:探讨利多卡因硬膜外阻滞复合全麻对肺癌患者术后相关指标的影响。方法:回顾性分析108例行手术治疗的肺癌患者资料,按麻醉方式的不同分为观察组(56例)和对照组(52例)。两组患者均静脉滴注异丙酚注射液和芬太尼注射液的复合液,并辅助吸入1%吸入用七氟醚辅助麻醉,间断静脉滴注注射用维库溴铵维持肌松。在此基础上,观察组患者硬膜外输注2.0%盐酸利多卡因注射液5 mL/h维持麻醉;对照组患者硬膜外输注0.9%氯化钠注射液5 mL/h维持麻醉。观察两组患者麻醉时间、手术时间、术中出血量、术后苏醒时间,芬太尼、异丙酚、维库溴铵、七氟醚使用量,术后麻醉相关并发症(恶心、呕吐、头晕、嗜睡、皮肤瘙痒)及其他并发症(心功能不全、心血管事件、房颤、感染、短暂性脑缺血、急性冠状动脉综合征、脑卒中)发生情况,术后4 h及1、2、3、4、5 d的活动与平静时疼痛视觉模拟(VAS)评分。结果:观察组患者麻醉时间、手术时间、术中出血量、术后苏醒时间,芬太尼、异丙酚、七氟醚使用量,术后4 h、1、2 d平静时的VAS评分及术后4 h、1、2、3 d活动时的VAS评分、嗜睡发生率均显著短于或低于对照组,头晕发生率显著高于对照组,差异均有统计学意义(P<0.05);两组患者维库溴铵使用量,其他时间平静与活动时的VAS评分,恶心、呕吐、皮肤瘙痒、心功能不全、心血管事件、房颤、感染、短暂性脑缺血、急性冠脉综合征及脑卒中发生率比较,差异均无统计学意义(P>0.05)。结论:利多卡因硬膜外阻滞复合全麻可减少肺癌患者术中出血量,降低术后疼痛程度,缩短术后苏醒时间,且未增加术后并发症的发生。
ABSTRACT: OBJECTIVE: To investigate the effects of lidocaine epidural block combined with general anesthesia on postoperative related indexes of lung cancer patients. METHODS: In retrospective analysis, 108 patients with lung cancer were divided into observation group (56 cases) and control group (52 cases) according to anesthesia method. Both groups were given intravenous dripping of Propofol injection combined with Fentanyl injection, inhaled 1% sevoflurane for inhalation to assist anesthesia and intermittent intravenous drip of Vecuronium for injection to maintain muscle relaxation. On this basis, observation group was treated with epidural infusion of 2.0% Lidocaine hydrochloride injection 5 mL/h to maintain anesthesia; control group was given epidural infusion of 0.9% Sodium chloride injection 5 mL/h to maintain anesthesia. The anesthesia time, operation time, intraoperative bleeding volume, postoperative recovery time, the amount of fentanyl, propofol, vecuronium bromide and sevoflurane, the occurrence of postoperative anesthesia complications (nausea, vomiting, dizziness, drowsiness, skin itching) and other complications (cardiac function insufficiency, cardiovascular events, atrial fibrillation, infection, transient cerebral ischemia, acute coronary comprehensive syndrome, cerebral apoplexy) were observed in 2 groups as well as active and calm VAS score 4 h and 1, 2, 3, 4, 5 after surgery. RESULTS: The anesthesia time, operation time, intraoperative bleeding volume, postoperative recovery time, the amount of fentanyl, propofol, vecuronium bromide and sevoflurane, calm VAS score 4 h, 1 d, 2 d after surgery and active VAS score 4 h, 1 d, 2 d, 3 d after surgery, the incidence of  drowsiness in observation group were significantly shorter or lower than control group, while the incidence of dizziness was significantly higher than control group, with statistical significance (P<0.05). There was no statistical significance in the amount of vecuronium, calm and active VAS score in other time, the incidence of nausea, vomiting, skin itching, cardiac function insufficiency, cardiovascular events, atrial fibrillation, infection, transient cerebral ischemia, acute coronary syndrome and stroke between 2 groups(P>0.05). CONCLUSIONS: Lidocaine epidural block combined with general anesthesia can reduce the perioperation bleeding amount, postoperative pain, shorten postoperative recovery time and do not increase postoperative complications.
期刊: 2017年第28卷第12期
作者: 符宝春,王涛,于新洲
AUTHORS: FU Baochun,WANG Tao,YU Xinzhou
关键字: 利多卡因;硬膜外阻滞;全身麻醉;肺癌;并发症
KEYWORDS: Lidocaine;Epidural block; General anesthesia; Lung cancer; Complication
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