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左卡尼汀对维持性血液透析患者炎症因子、氧化应激指标及心脏功能的影响
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| 篇名： | 左卡尼汀对维持性血液透析患者炎症因子、氧化应激指标及心脏功能的影响 |
| TITLE： | |
| 摘要： | 目的：探讨左卡尼汀对维持性血液透析患者炎症因子、氧化应激指标、心脏功能的影响。方法：选择我院2014年12月－2016年2月维持性血液透析患者120例，按照随机数字表法分为观察组和对照组，各60例。对照组患者给予维持性血液透析，透析1个月后皮下注射重组人促红素注射液3 000 IU，3次/周；观察组患者在对照组基础上于透析结束后隔日给予注射用左卡尼汀2 g，iv，qod。两组患者均连续治疗3个月。观察两组患者治疗前后炎症因子[白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）、C反应蛋白（CRP）]、氧化应激指标[丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）]、心脏功能指标[心排血量（CO）、左室射血分数（LVEF）、室间隔舒张末期厚度（LVST）]水平，并记录不良反应发生情况。结果：治疗前，两组患者炎症因子、氧化应激指标和心脏功能指标比较，差异均无统计学意义（P＞0.05）。治疗后，观察组患者IL-6、TNF-α、CRP和MDA水平较治疗前明显降低，GSH-Px、SOD、CO和LVEF水平明显升高，且观察组上述指标改善程度明显优于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗过程中均未见明显不良反应。结论：左卡尼汀能够有效缓解维持性血液透析患者的微炎症状态，保护心脏功能，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of L-carnitine on inflammatory factor， oxidant stress index and cardiac function in patients with maintenance hemodialysis. METHODS： One hundred and twenty maintenance hemodialysis patients selected from our hospital during Dec. 2014-Feb. 2016 were randomly divided into observation group and control group， with 60 cases in each group. Control group received maintenance hemodialysis for 1 month， and then was given rhEPO injection 3 000 IU subcutaneously， 3 times a week. Observation group was additionally given Levocarnitine for injection 2 g， iv， qod， 1 day after hemodialysis， on the basis of control group. Two groups were treated for consecutive 3 months. The levels of inflammatory factors （IL-6， TNF-α， CRP）， oxidant stress indexes （MDA， GSH-Px， SOD） and cardiac function indexes （CO， LVEF， LVST） were observed in 2 groups before and after treatment； the occurrence of ADR was recorded. RESULTS： There was no statistical significance in inflammatory factor， oxidant stress index and cardiac fuaction before treatment between 2 groups （P＞0.05）. After treatment， the levels of IL-6， TNF-α， CRP and MDA in observation group were decreased significantly， while the levels of GSH-Px， SOD， CO and LVEF were increased significantly， compared to before treatment； the improvement of above indexes in observation group were significantly better than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： L-carnitine can effectively alleviate the micro-inflammatory state in maintenance hemodialysis patients and protect myocardial function with good safety. |
| 期刊： | 2017年第28卷第11期 |
| 作者： | 徐海平，李秀丽，孙立娜，孙福云 |
| AUTHORS： | XU Haiping，LI Xiuli，SUN Lina，SUN Fuyun |
| 关键字： | 左卡尼汀；维持性血液透析；微炎症状态；炎症因子；氧化应激指标；心脏功能 |
| KEYWORDS： | L-carnitine； Maintenance hemodialysis； Micro inflammatory state； Inflammatory factor； Oxidant stress index； Cardiac function |
| 阅读数： | 349 次 |
| 本月下载数： | 6 次 |
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