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吉西他滨结合放、化疗对宫颈癌血管生成及侵袭能力的影响
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| 篇名： | 吉西他滨结合放、化疗对宫颈癌血管生成及侵袭能力的影响 |
| TITLE： | |
| 摘要： | 目的：探讨吉西他滨结合放、化疗对宫颈癌血管生成及侵袭能力的影响。方法：选取2015年1月－2016年6月重庆市开州区人民医院收治的拟行手术的宫颈癌患者37例，按照随机数字表法分为观察组（n＝19）和对照组（n＝18）。对照组患者给予三维适形放疗和化疗，化疗方案为顺铂注射液70 mg/m2，ivgtt+氟尿嘧啶注射液600 mg/m2，ivgtt，放疗后第1、21天给药；观察组患者在对照组基础上给予注射用盐酸吉西他滨800 mg/m2，ivgtt，放疗后第1、8天给药。两组患者均以28 d为1个周期，治疗2个周期后行广泛性子宫切除术和盆腔淋巴结清扫术。观察两组患者临床疗效、肿瘤微血管密度（MVD）、血管内皮生长因子（VEGF）、细胞外因子蛋白（Wnt）1、Wnt3a、Wnt8和β-链蛋白（β-catenin）通路水平，分析MVD与VEGF的相关性，并记录不良反应发生情况。结果：观察组患者临床总有效率（84.2％）明显高于对照组（50.0％），差异有统计学意义（P＜0.05）。两组患者病灶组织MVD、VEGF、Wnt1、Wnt3a、Wnt8和β-catenin水平均明显高于健康组织，观察组患者病灶组织上述指标水平均明显低于对照组病灶组织，差异均有统计学意义（P＜0.05）。MVD与VEGF水平呈正相关性。两组患者不良反应发生率比较，差异无统计学意义（31.6％ vs. 27.8％，P＞0.05）。结论：吉西他滨结合放、化疗可有效调控宫颈癌细胞血管生成和Wnt/β-catenin信号通路活性，降低宫颈癌细胞的侵袭能力，可能为其发挥抗癌作用的重要机制之一，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of gemcitabine combined with radiotherapy and chemotherapy on angiogenesis and cell invasion ability of cervical cancer. METHODS： Totally 37 patients undergoing radical operation selected from Chongqing Kaizhou District People’s Hospital during Jan. 2015-Jun. 2016 were divided into observation group （n＝19） and control group （n＝18）. Control group was given 3-D conformal radiation and chemotherapy which included Cisplatin injection 70 mg/m2，ivgtt+Fluorouracil injection 600 mg/m2，ivgtt on 1st and 21st day after radiotherapy. Observation group was additionally given Gemcitabine hydrochloride for injection 800 mg/m2，ivgtt， 1st and 8th day after radiotherapy. A treatment course lasted for 28 d. The radical hysterectomy and pelvic lymphadenectomy were conducted after 2 courses of treatment. Clinical efficacy， microvessel density （MVD） of tumor， vascular endothelial growth factor （VEGF）， Wnt1， Wnt3a， Wnt8 and β-catenin level were observed in 2 groups. The relationship of MVD with VEGF was analyzed， and the occurrence of ADR was recorded. RESULTS： The total response rate of observation group （84.2％） was significantly higher than control group， with statistical significance （P＜0.05）. The levels of MVD， VEGF， Wnt1， Wnt3a， Wnt8 and β-catenin in 2 groups were significantly higher than healthy tissue； above indexes of focus tissue in observation group were significantly lower than control group， with statistical significance （P＜0.05）. MVD was positively correlated with VEGF. There was no statistical significance in the incidence of ADR between 2 groups （31.6％ vs. 27.8％， P＜0.05）. CONCLUSIONS： Gemcitabine combined with radiotherapy and chemotherapy can regulate the angiogenesis of cervical cancer cell and the activity of Wnt/β-catenin signal pathway， and reduce the invasion ability of cervical cancer cell， which may be the important mechanism of anti-tumor effect with good safety. |
| 期刊： | 2017年第28卷第11期 |
| 作者： | 蒋晓蓉，李万平，熊林 |
| AUTHORS： | JIANG Xiaorong，LI Wanping，XIONG Lin |
| 关键字： | 吉西他滨；宫颈癌；血管内皮生长因子；肿瘤微血管密度；细胞侵袭；Wnt通路 |
| KEYWORDS： | Gemcitabine； Cervical cancer； Vascular endothelial growth factor； Microvascular density of tumor； Cell invasion； Wnt pathway |
| 阅读数： | 297 次 |
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