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复方银杏叶颗粒对急性胰腺炎肝功能损害的保护作用
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| 篇名： | 复方银杏叶颗粒对急性胰腺炎肝功能损害的保护作用 |
| TITLE： | |
| 摘要： | 目的：探讨复方银杏叶颗粒对急性胰腺炎肝功能损害的保护作用。方法： 选取2013年9月－2015年9月我院收治的重症急性胰腺炎（SAP）合并肝功能损害患者82例，采用随机数字表法分为对照组和观察组，各41例。对照组患者给予SAP相关常规治疗；观察组患者在对照组基础上给予复方银杏叶颗粒5 g加入温开水80 mL中溶解后经鼻饲胃管注入，tid。1周为1个疗程，共治疗2个疗程。观察两组患者腹痛缓解时间、血清淀粉酶恢复时间、住院时间及不良反应发生情况，检测两组患者治疗前后血清淀粉酶、丙氨酸转氨酶（ALT）、总胆红素（TBIL）、天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（γ-GT）、白蛋白（ALB）、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）、肉毒素浓度、丙二醛（MDA）、过氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、总抗氧化能力（TAC）、外周血中性粒细胞中核因子-κB（NF-κB）水平。结果：对照组患者脱落3例，38例完成研究；观察组患者脱落6例，35例完成研究。观察组患者腹痛缓解时间、血清淀粉酶恢复时间、住院时间明显短于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗前血清淀粉酶、ALT、TBIL、AST、γ-GT、ALB、IL-6、TNF-α、肉毒素浓度、MDA、SOD、GSH-Px、TAC、NF-κB水平比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者血清淀粉酶、ALT、TBIL、AST、γ-GT、IL-6、TNF-α、肉毒素浓度、NF-κB、MDA水平显著降低， ALB、SOD、GSH-Px、TAC水平显著升高，且观察组显著优于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：复方银杏叶颗粒能显著降低患者血清淀粉酶水平，保护肝功能，且安全性较好；其机制可能与抑制炎症因子释放、改善氧化应激反应、降低肉毒素浓度、抑制NF-κB活化有关。 |
| ABSTRACT： | OBJECTIVE： To investigate the protective effect of Compound ginkgo leaf granules on liver function damage of acute pancreatitis. METHODS： Totally 82 patients with severe acute pancreatitis （SAP） complicated with liver function damage selected from our hospital during Sept. 2013-Sept. 2015 were randomized into control group and observation group according to random number table， with 41 cases in each group. Control group was given SAP related routine therapy. On the basis of the control group， observation group was additionally given Compound ginkgo leaf granules 5 g added into warm boiled water 80 mL via nasogastric tube， tid， one week as a treatment course， for 2 courses. The remission time of abdominal pain， serum amylase recovery time， length of hospital stay and adverse drug reactions were observed in 2 groups. The levels of serum amylase， ALT， TBIL， AST， γ-GT， ALB， IL-6， TNF-α， creotoxin concentration， MDA， SOD， GSH-Px， total antioxidant capacity （TAC） and peripheral blood PMN NF-κB levels were determined in 2 groups before and after treatment. RESULTS： In control group， 3 patients withdrew from the study and 38 patients completed the study； in observation group， 6 patients withdrew from the study and 35 patients completed the study. The remission time of abdominal pain， recovery time of serum amylase and the length of hospital stay in observation group were significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in the levels of serum amylase， ALT， TBIL， AST， γ-GT， ALB， IL-6， TNF-α， creotoxin concentration， MDA， SOD， GSH-Px， TAC and NF-κB between 2 groups （P＞0.05）. After treatment， the levels of serum amylase， ALT， TBIL， AST， γ-GT， IL-6， TNF-α， creotoxin concentration， NF-κB and MDA in 2 groups were decreased significantly， while the levels of ALB， SOD， GSH-Px and TAC were increased significantly； the observation group was significantly lower or higher than the control group，with statistically significant （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Compound ginkgo leaf granules can significantly decrease serum amylase， protect liver function， with good safety. The mechanismmay be inhibiting the release of inflammatory factors， improving oxidative stress reactions， reduce the concentration of creotoxin and inhibiting the activity of NF-κB. |
| 期刊： | 2017年第28卷第11期 |
| 作者： | 胡永梅，王海燕，秦丽静 |
| AUTHORS： | HU Yongmei，WANG Haiyan，QIN Lijing |
| 关键字： | 急性胰腺炎；复方银杏叶颗粒；肝功能；炎症因子；氧化应激；保护机制 |
| KEYWORDS： | Acute pancreatitis； Compound ginkgo leaf granules； Liver function； Inflammatory factor； Oxidative stress； Protective mechanism |
| 阅读数： | 334 次 |
| 本月下载数： | 3 次 |
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