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左乙拉西坦添加治疗老年癫痫患者的临床观察
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| 篇名： | 左乙拉西坦添加治疗老年癫痫患者的临床观察 |
| TITLE： | |
| 摘要： | 目的：考察左乙拉西坦添加治疗老年癫痫患者的临床效果及安全性。方法：将2014年1月－2016年1月于重庆市云阳县中医院就诊的老年癫痫患者88例按照随机数字表法分为观察组与对照组，各44例。对照组患者给予卡马西平+苯巴比妥常规抗癫痫治疗；观察组患者在对照组基础上加用左乙拉西坦片，初始剂量0.25 g，后期根据患者病情可增至0.5 g，bid。两组疗程均为6个月。观察两组患者的临床疗效、格拉斯哥昏迷评分法（GCS）评分、巴塞尔（Barthel）指数评分、蒙特利尔认知评估量表（MoCA）评分和不良反应发生情况。结果：观察组患者的总有效率、控制率和MoCA评分均显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗后的GCS和Barthel指数评分均明显高于治疗前，且观察组患者的2项评分均明显高于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：采用左乙拉西坦添加治疗老年癫痫的疗效优于常规治疗方案，使患者的昏迷程度显著降低，日常生活能力与认知功能显著提高，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy and safety of levetiracetam add-on therapy in the treatment of elderly epileptic patients. METHODS： Totally 88 elderly epileptic patients in Chongqing Yunyang County Hospital of TCM during Jan. 2014-Jan. 2016 were divided into observation group and control group according to random number table， with 44 cases in each group. Control group was given routine antiepileptic therapy of carbamazepine+phenobarbital； observation group was additionally given Levetiracetam tablet with initial dose of 0.25g， increasing to 0.5 g according to disease condition， bid， on the basis of control group. Treatment courses of 2 groups lasted for 6 months. Clinical efficacies， GCS score， Barthel index score， MoCA score and the occurrence of ADR were observed in 2 groups. RESULTS： Total response rate， control rate and MoCA score of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）. GCS and Barthel index score of 2 group after treatment were significantly higher than before treatment， and those 2 scores of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Levetiracetam add-on therapy is better than routine therapy plan in the treatment of elderly epilepsy， and significantly reduce coma degree， increase daily living ability and cognitive function with good safety. |
| 期刊： | 2017年第28卷第11期 |
| 作者： | 万令，雷华 |
| AUTHORS： | WAN Ling，LEI Hua |
| 关键字： | 左乙拉西坦；老年患者；癫痫；昏迷；日常生活能力；认知功能 |
| KEYWORDS： | Levetiracetam； Elderly patient； Epilepsy； Coma； Daily living ability； Cognitive function |
| 阅读数： | 318 次 |
| 本月下载数： | 2 次 |
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