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糠酸氟替卡松鼻用喷雾剂治疗变应性鼻炎的临床研究
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| 篇名： | 糠酸氟替卡松鼻用喷雾剂治疗变应性鼻炎的临床研究 |
| TITLE： | |
| 摘要： | 目的：探讨糠酸氟替卡松鼻用喷雾剂治疗变应性鼻炎（AR）的临床效果及安全性。方法：将2014年1月－2015年12月在我院治疗的AR患者100例采用随机数字表法分为对照组和观察组，各50例。两组患者均给予减充血剂盐酸羟甲唑啉喷雾剂喷鼻。在此基础上，对照组患者给予布地奈德鼻喷雾剂喷鼻，用药第1天每个鼻孔喷1次，第2天每个鼻孔各2次，之后可根据病情适当增加喷鼻次数，但年龄≤14岁的患儿每日用量不超过6喷，年龄＞14岁的患者每日用量不超过8喷；观察组患者给予糠酸氟替卡松鼻用喷雾剂喷鼻，年龄≤14岁的患儿每个鼻孔喷1次（qd），年龄＞14岁的患者每个鼻孔喷1次（早晚各1次）。两组均持续治疗30 d。比较两组患者治疗前后鼻部症状总评分（TNSS）和眼部症状总评分（TESS），75、150 Pa压力下的鼻腔总阻力值（TNR）与鼻腔最小横截面积（MCA），以及不良反应发生情况。结果：治疗前，两组患者上述指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者的TNSS评分和观察组患者的TESS评分均较治疗前显著下降，且观察组的TESS评分显著低于对照组，差异均有统计学意义（P＜0.05），但对照组患者的TESS评分在治疗前后比较，差异无统计学意义（P＞0.05）；两组患者在75、150 Pa压力下的TNR均显著小于治疗前，且观察组均小于对照组，差异均有统计学意义（P＜0.05）；两组患者的MCA均显著小于治疗前，但组间比较差异无统计学意义（P＞0.05）。观察组患者的不良反应发生率显著低于对照组，差异有统计学意义（P＜0.05）。结论：糠酸氟替卡松对AR患者鼻部症状的改善效果与布地奈德相当，但对眼部症状及鼻通气功能的改善效果优于布地奈德，且不良反应较少。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy and safety of Fluticasone furoate nasal spray in the treatment of allergic rhinitis （AR）. METHODS： 100 AR patients in our hospital during Jan. 2014-Dec. 2015 were divided into control group and observation group according to random number table， with 50 cases in each group. Both groups received decongestant Oxymetazoline hydrochloride spray. Control group was additionally given Budesonide spray， once each nostril on the first day， twice each nostril on the second day， increasing suitably according to disease condition， less than 6 times a day for patients younger than 14 years old， less than 8 times a day for patients older than 14 years old； observation group was additionally given Fluticasone furoate nasal spray， once each nostril， qd for patients younger than 14 years old， once each nostril， while morning and night for patients older than 14 years old. Both groups received treatment for consecutive 30 d. The total nasal symptoms score （TNSS）， total eye symptoms score （TESS）， total nasal resistance （TNR） under 75， 150 Pa， nasal minimum cross-sectional area （MCA） and the occurrence of ADR were compared between 2 groups before and after treatment. RESULTS： There was no statistical significance in above indexes between 2 groups before treatment （P＞0.05）. After treatment， TNSS of 2 groups and TESS of observation group were decreased significantly compared to before treatment， and TESS of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in TESS of control group before and after treatment （P＞0.05）. TNR of 2 groups under 75， 150 Pa were significantly lower than before treatment， and the observation group was lower than the control group， with statistical significance （P＜0.05）. MCA of 2 groups were significantly lower than before treatment， without statistical significance between 2 groups （P＞0.05）. The incidence of ADR in observation group was significantly lower than control group， with statistical significance （P＜0.05）. CONCLUSIONS： Fluticasone furoate is similar to budesonide in the treatment of nasal symptoms of AR patients， but it is better than budesonide in improving eye symptoms and nasal ventilation function with milder ADR. |
| 期刊： | 2017年第28卷第11期 |
| 作者： | 杨琛，魏鑫鑫，尹中普 |
| AUTHORS： | YANG Chen，WEI Xinxin，YIN Zhongpu |
| 关键字： | 变应性鼻炎；糠酸氟替卡松；布地奈德；鼻通气功能 |
| KEYWORDS： | Allergic rhinitis； Fluticasone furoate； Budesonide； Nasal ventilation function |
| 阅读数： | 784 次 |
| 本月下载数： | 8 次 |
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