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益母草注射液联合卡前列素氨丁三醇用于预防剖宫产产后出血的临床观察
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| 篇名： | 益母草注射液联合卡前列素氨丁三醇用于预防剖宫产产后出血的临床观察 |
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| 摘要： | 目的：观察益母草注射液联合卡前列素氨丁三醇用于预防剖宫产产后出血的疗效和安全性。方法：177例拟行剖宫产妊娠期妇女随机分为对照组（87例）和观察组（90例）。两组妊娠期妇女均行剖宫产术，对照组妊娠期妇女于胎儿娩出后立即向切口上方的子宫肌壁注射缩宫素20 U，后给予20 U缩宫素加入0.9％氯化钠注射液250 mL中，静脉滴注，术后4 h肌内注射缩宫素10 U，后每12 h肌内注射1次，连用3 d；观察组妊娠期妇女于胎儿娩出后立即向子宫切口处肌内注射益母草注射液2 mL，卡前列素氨丁三醇注射液1 mL，术后4 h再次肌内注射益母草注射液2 mL，卡前列素氨丁三醇注射液1 mL，后每12 h肌内注射益母草注射液2 mL，连用3 d。观察两组妊娠期妇女的临床疗效，术中、术后2 h、术后24 h出血量，术前及术后24 h血红蛋白（Hb）水平，产后3、7 d宫底高度及不良反应发生情况。结果：观察组妊娠期妇女总有效率显著高于对照组，术中、术后2 h、术后24 h出血量及产后3、7 d宫底高度均显著低于对照组，差异均有统计学意义（P＜0.05）。术前，两组妊娠期妇女Hb水平比较，差异均无统计学意义（P＞0.05）。术后24 h，对照组妊娠期妇女Hb水平均显著低于同组术前及观察组，差异均有统计学意义（P＜0.05）；观察组妊娠期妇女术前、术后24 h Hb水平比较，差异均无统计学意义（P＞0.05）。两组妊娠期妇女不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：益母草注射液联合卡前列素氨丁三醇用于妊娠期妇女剖宫产产后出血的疗效显著，可明显降低术中及术后出血量，加快子宫复旧，且未增加不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of Leonurus artemisia injection combined with carboprost tromethamine for preventing postpartum hemorrhage （PPH） of pregnant women after cesarean section. METHODS： 177 pregnant women undergoing cesarean section were randomly divided into control group （87 cases） and observation group （90 cases）. Pregnant women of both groups received cesarean section. Control group was given intramuscular injection of oxytocin 20 U in uterine muscle wall above the incision after the foetus parturition， and given intravenous dripping of oxytocin 20 U added into 0.9％ sodium chloride 250 mL； 4 h after the operation， the pregnant women received intramuscular injection of oxytocin 10 U， every 12 hours， for 3 days. Observation group was given intramuscular injection of L. artemisia injection 2 mL and Carboprost tromethamine injection 1 mL in uterine incision after the foetus parturition； 4 h after the operation， the pregnant women received intramuscular injection of L. artemisia injection 2 mL and Carboprost tromethamine injection 1 mL， and then give L. artemisia injectien 2 mL， every 12 hours， for 3 days. Clinical efficacies of 2 groups were observed as well as blood loss during operation， 2 h after operation and 24 h after operation， the amount of hemoglobin （Hb） before operation and 24 h after operation， height of uterine fundus 3， 7 d after operation， the occurrence of ADR. RESULTS： The total response rate of observation group was significantly higher than that of control group； blood loss during operation， 2 h after operation and 24 h after operation， height of uterine fundus 3， 7 d after operation were also significantly than control group， with statistical significance （P＜0.05）. There was no statistical significance in Hb of pregnant women between 2 groups before operation（P＞0.05）. 24 h after operation， Hb of pregnant women in control group was significantly lower than before operation and observation group， with statistical significance （P＜0.05）； there was no statistical significance in Hb of observation group between before operation and 24 h after operation （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： L. artemisia injection combined with carboprost tromethamine shows significant therapeutic efficacy for PPH of pregnant women underwent cesarean section， can significantly reduce intraoperative and postoperative blood loss， accelerates the recovery of uterus without increasing the rate of ADR. |
| 期刊： | 2017年第28卷第9期 |
| 作者： | 李玉梅，谭白菊 |
| AUTHORS： | LI Yumei，TAN Baiju |
| 关键字： | 益母草注射液；卡前列素氨丁三醇；剖宫产；产后出血；疗效；安全性 |
| KEYWORDS： | Leonurus artemisia injection； Carboprost tromethamine； Cesarean section； Postpartum hemorrhage； Efficacy； Safety |
| 阅读数： | 325 次 |
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