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美他多辛联合硫普罗宁治疗酒精性肝病的疗效观察
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| 篇名： | 美他多辛联合硫普罗宁治疗酒精性肝病的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察美他多辛联合硫普罗宁治疗酒精性肝病的临床疗效。方法：回顾性选取山西省人民医院和太原市第三人民医院2013年10月－2015年12月就诊的70例酒精性肝病患者资料，按照治疗方案分为治疗组和对照组，各35例。对照组患者在基础治疗方案上给予硫普罗宁肠溶片0.2 g，po，tid；治疗组患者在对照组基础上给予美他多辛片1.0 g，po，bid。两组患者疗程均为6周。观察两组患者治疗前后丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、γ-谷氨酰转肽酶（γ-GT）、 总胆红素（TBIL）、总胆固醇（TC）、三酰甘油（TG）和清蛋白球蛋白比值（A/G）等指标水平，血清Ⅳ型胶原（Ⅳ-C）、透明质酸（HA）和层黏连蛋白（Ln）等肝纤维指标水平，门静脉（MPV）、脾静脉（SPV）直径和脾厚以及临床疗效，并记录不良反应发生情况。结果：两组患者血清ALT、AST、γ-GT、TBIL、TC、TG水平均明显下降，A/G水平明显上升，且治疗组患者上述指标变化较对照组更为显著，差异均有统计学意义（P＜0.05）；治疗组患者血清Ⅳ-C、HA、Ln、MPV、SPV和脾厚等均明显下降/减小，且明显低于对照组，差异均有统计学意义（P＜0.05）。治疗组患者总有效率（94.29％）明显高于对照组（62.86％），差异有统计学意义（P＜0.05）。两组患者治疗过程中均未见明显不良反应发生。结论：美他多辛联合硫普罗宁治疗酒精性肝病疗效较好，且安全性高。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy of metadoxine combined with tiopronin in the treatment of alcoholic liver disease. METHODS： In retrospective study， 70 patients with alcoholic liver disease were selected from Shanxi Provincial People’s Hospital and Taiyuan Third People’s Hospital during Oct. 2013-Dec. 2015， and then divided into treatment group and control group with 35 cases in each group according to therapy plan. Control group was additionally given Tiopronin enteric-coated tablet 0.2 g， po， tid， based on routine treatment； treatment groups was additionally Metadoxine tablet 1.0 g，po，bid， on the basis of control group. Both groups received treatment for 6 weeks. Serum indicators as ALT， AST， γ-GT， TBIL， TC， TG and A/G and serum hepatic fibrosis indicators as Ⅳ-C， HA and Ln were observed in 2 groups before and after treatment as well as the diameters of MPV and SPV， spleen thickness and clinical efficacy. The occurrence of ADR was recorded. RESULTS： The serum levels of ALT， AST， γ-GT， TBIL， TC and TG were decreased significantly in 2 groups， while A/G level was increased significantly； above indicators of treatment group were more significant than those of control group， with statistical significance （P＜0.05）. Serum levels of Ⅳ-C， HA， Ln， MPV， SPV and spleen thickness in treatment group were significantly decreased and lower than in control group， with statistical significance （P＜0.05）. Total response rate of treatment group （94.29％） was significantly higher than that of control group （62.86％）， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Metadoxine combined with tiopronin shows good therapeutic efficacy for alcoholic liver disease with good safety. |
| 期刊： | 2017年第28卷第8期 |
| 作者： | 董晋钢，董晋瑛 |
| AUTHORS： | DONG Jingang，DONG Jinying |
| 关键字： | 酒精性肝病；硫普罗宁；美他多辛；疗效 |
| KEYWORDS： | Alcoholic liver disease； Tiopronin； Metadoxine； Therapeutic efficacy |
| 阅读数： | 331 次 |
| 本月下载数： | 3 次 |
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