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重组人血管内皮抑制素治疗瘢痕疙瘩的临床观察
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| 篇名： | 重组人血管内皮抑制素治疗瘢痕疙瘩的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨重组人血管内皮抑制素治疗瘢痕疙瘩的有效性及安全性。方法：将2015年1月－2016年1月在南充市中心医院就诊的瘢痕疙瘩患者64例按随机数字表法分为观察组和对照组，各32例。两组患者均进行点阵CO2激光治疗。术后，对照组患者常规给予抗氧化药物和抗菌药物治疗；观察组患者在对照组治疗基础上加用重组人血管内皮抑制素注射液0.1～0.2 mg/cm2进行瘢痕瘤体注射，每月1次，共注射2次。比较两组患者的临床疗效、激光治疗后和治疗2个月后的症状评分、创面愈合时间、治疗前后的创面色素沉着面积和瘢痕面积，以及不良反应发生情况。结果：观察组和对照组患者的总有效率（93.75％ vs. 87.50％）和不良反应发生率（15.63％ vs. 12.50％）比较，差异均无统计学意义（P＞0.05）。治疗2个月后，对照组患者的各项症状评分与激光治疗后比较，差异均无统计学意义（P＞0.05）；观察组患者红斑、水肿和色素沉着评分明显低于治疗前及对照组，差异均有统计学意义（P＜0.05）；两组患者瘙痒和灼痛感评分比较，差异无统计学意义（P＞0.05）；观察组患者的创面结痂时间、脱痂时间及创面完全愈合时间均明显短于对照组，差异均有统计学意义（P＜0.05）；两组患者的色素沉着面积和瘢痕面积均明显小于治疗前，且观察组均明显小于对照组，差异均有统计学意义（P＜0.05）。结论：重组人血管内皮抑制素治疗瘢痕疙瘩可有效缓解红斑、水肿、色素沉着等症状，缩短创面愈合时间，可有效抑制色素沉着及瘢痕的再生，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate effectiveness and safety of rh-endostatin in the treatment of keloid. METHODS： Sixty-four keloid patients in Nanchong Central Hospital during Jan. 2015-Jan. 2016 were divided into observation group and control group by random number table， with 32 cases in each group. Both group received fractional CO2 laser treatment. After surgery， control group was given antioxidant drug and antibiotics routinely. Observation group was additionally given Rh-endostatin injection 0.1-0.2 mg/cm2 via keloid body， once a month， for twice， on the basis of control group. Clinical efficacy， symptom score after laser treatment and 2 months after laser treatment， wound healing time， wound pigmentation area and keloid area before and after treatment， the occurrence of ADR were compared between 2 groups. RESULTS： There was no statistical significance in total response rate （93.75％ vs. 87.50％） and the incidence of ADR （15.63％ vs. 12.50％） between observation group and control group （P＞0.05）. There was no statistical significance in symptom score of control group between after laser treatment and after 2 months of treatment （P＞0.05）. The erythema， edema and pigmentation scores of observation group were significantly lower than before treatment and control group， with statistical significance （P＜0.05）； there was no statistical significance in skin itching and burning sensation score between 2 groups （P＞0.05）. The wound incrustation time， decrustation time and wound healing time of observation group were significantly shorter than those of control group， with statistical significance （P＜0.05）. Pigmentation area and keloid area of 2 groups were significantly smaller than before， and the observation group was significantly smaller than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Rh-endostatin can alleviate erythema， edema， pigmentation and other symptoms effectively， shorten healing time， and inhibit pigmentation and keloid regeneration effectively with good safety. |
| 期刊： | 2017年第28卷第8期 |
| 作者： | 田超，游晓波，许尔长，高华伟，蒲晓姝 |
| AUTHORS： | TIAN Chao，YOU Xiaobo，XU Erchang，GAO Huawei，PU Xiaoshu |
| 关键字： | 瘢痕疙瘩；重组人血管内皮抑制素；色素沉着；促血管生长因子 |
| KEYWORDS： | Keloid； Rh-endostatin； Pigmentation； Angiogenic growth factor |
| 阅读数： | 286 次 |
| 本月下载数： | 4 次 |
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