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我院21例利培酮致白细胞减少的不良反应报告分析
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| 篇名： | 我院21例利培酮致白细胞减少的不良反应报告分析 |
| TITLE： | |
| 摘要： | 目的：分析利培酮导致白细胞减少的不良反应特点。方法：收集并分析2004－2015年我院上报的21例利培酮致白细胞减少的不良反应病例并进行分析，探讨利培酮导致白细胞减少的特点。结果：21例患者中，男性10例，女性11例。年龄15～72岁，其中31～40岁有9例，占42.9％。原患疾病以精神分裂症为主，患者均为口服用药，用药剂量为正常剂量，用药至发生白细胞减少的潜伏期为（28.6±21.4）d。发生不良反应时，患者均无不适的主诉，白细胞计数均值为（3.1±0.5）×109 L－1，经减量、停药及对症处理均好转。结论：利培酮致白细胞减少时，患者通常无躯体不适的主诉，临床需定期监测、尽早识别、谨慎处理。 |
| ABSTRACT： | OBJECTIVE： To analyze the features of risperidone-induced leucocytopenia ADR. METHODS： Twenty-one ADR cases of risperidone-induced leucocytopenia reported by our hospital were collected and analyzed during 2004-2015. The characteristics of risperidone-induced leucocytopenia were discussed. RESULTS： Among 21 patients， there were 10 male and 11 female. The age was from 15 to 72 years old. Nine cases of patients were 31-40 years old （42.9％）. Most of the original disease was schizophrenia. Incubation period of leucocytopenia caused by risperidone was （28.6±21.4） d. Patients had no discomfort complain when leucocytopenia occurred. The lowest white blood cells reported was（3.1±0.5）×109 L－1. The leucocytopenia were improved after reduction， drug withdrawal and symptomatic treatment. CONCLUSIONS： Patients usually have no body discomfort complain when risperidone-induced leucocytopenia appears. Doctors should moniter ADR regularly， identify it earlier and treat carefully. |
| 期刊： | 2017年第28卷第8期 |
| 作者： | 庄红艳，刘珊珊，果伟，马辛，郝红兵，梁海霞，王秋艳 |
| AUTHORS： | ZHUANG Hongyan，LIU Shanshan，GUO Wei，MA Xin，HAO Hongbing，LIANG Haixia，WANG Qiuyan |
| 关键字： | 利培酮；白细胞减少；不良反应；合理用药 |
| KEYWORDS： | Risperidone； Leucocytopenia； Adverse drug reaction； Rational drug use |
| 阅读数： | 441 次 |
| 本月下载数： | 10 次 |
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