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阿苯达唑纳米脂质体冻干粉的制备及性质考察
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| 篇名： | 阿苯达唑纳米脂质体冻干粉的制备及性质考察 |
| TITLE： | |
| 摘要： | 目的：制备阿苯达唑纳米脂质体冻干粉并对其性质进行考察。方法：利用冷冻干燥法制备阿苯达唑纳米脂质体冻干粉，以粒径、包封率联合外观、再分散性为指标，采用单因素试验联合正交试验筛选冻干处方工艺。考察冻干前、后脂质体的形态学变化、粒径、Zeta电位、水分含量、4 ℃下12个月的稳定性。结果：采用外加冻干保护剂的总量为10％，其中葡萄糖-海藻糖-甘露醇配比为1.0 ∶ 1.0 ∶ 3.0，以速冻的方式，于－35 ℃冰箱预冻18 h，冷冻干燥48 h获得冻干粉。与冻干前比较，冻干后脂质体形态未发生明显变化，可见清晰的磷脂双分子层膜结构；冻干前、后脂质体的粒径分别为（208.63±1.04）、（223.04±2.02） nm，Zeta电位分别为 （－15.6±0.04）、（－19.4±0.06） mV，包封率分别为（94.62±0.49）％、（91.10±0.46）％（n＝3）；与脂质体比较，脂质体冻干粉在4 ℃下12个月较稳定。结论：成功制得阿苯达唑纳米脂质体冻干粉，其稳定性优于阿苯达唑纳米脂质体，冻干工艺可行。 |
| ABSTRACT： | OBJECTIVE： To prepare the Albendazole nanoliposomes freeze-dried power and study its properties. METHODS： Freeze-drying method was conducted to prepare Albendazole nanoliposomes freeze-dried power， using the particle size， encapsulation efficiency， appearance， redispersibility as indexes， single factor test was combined with orthogonal test to screen freeze-drying preparation technology. The morphological changes， particle size， Zeta potential， moisture content， 12 months stability at 4 ℃ before and after freeze-drying were detected. RESULTS： Plus a total content of freeze-dried protective agent was 10％， the ratio of glucose-trehalose-mannitol was 1.0 ∶ 1.0 ∶ 3.0， using quick-freeze， pre-freezing 18 h in －35 ℃ refrigerator， dry-freezing 48 h to obtain freeze-dried powder. Compared with before freeze-drying， the freeze-dried liposomal morphology had no obvious changes， showing clear phospholipid bilayer membrane structure； the particle sizes before and after freeze-drying were （208.63±1.04） nm and （223.04±2.02） nm， Zeta potentials were （－15.6±0.04） mV and （－19.4±0.06） mV， encapsulation efficiencies were （94.62±0.49）％ and （91.10±0.46）％ （n＝3）， respectively. Compared with liposomes， liposomes freeze-dried power had good stability in 12 months at 4 ℃. CONCLUSIONS： Albendazole nanoliposomes freeze-dried power is prepared successfully， its stability is superior to albendazole nanoliposomes， and the freeze-drying technology is feasible. |
| 期刊： | 2017年第28卷第7期 |
| 作者： | 陈蓓，陈春燕，高惠静，王建华，赵军 |
| AUTHORS： | CHEN Bei，CHEN Chunyan，GAO Huijing，WANG Jianhua，ZHAO Jun |
| 关键字： | 阿苯达唑；纳米脂质体；冻干粉；粒径；包封率；稳定性；正交试验 |
| KEYWORDS： | Albendazole； Nanoliposomes； Freeze-dried powder； Particle size； Encapsulation efficiency； Stability； Orthogonal test |
| 阅读数： | 425 次 |
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