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星点设计-响应面法优化壮骨方煮散的煎煮工艺
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| 篇名： | 星点设计-响应面法优化壮骨方煮散的煎煮工艺 |
| TITLE： | |
| 摘要： | 目的：优化壮骨方煮散的煎煮工艺。方法：采用2因素5水平星点设计试验，以加水（倍）量和煎煮时间为自变量，以淫羊藿苷提取量和浸膏得率的总评“归一值”为因变量，进行回归方程拟合，采用响应面法优化壮骨方煮散煎煮工艺并进行验证；将采用优化后煎煮工艺的煮散与传统饮片的煎煮效果进行比较。结果：最优工艺为加16 倍量水，煎煮2 次，每次20 min；验证试验中 “归一值”预测值与理论值的相对误差为2.97％；煮散与饮片经相同条件煎煮后淫羊藿苷提取量分别为1.234 3 、1.132 4 μg/g，浸膏得率分别为23.73％、17.84％。结论：星点设计-响应面法优化煎煮工艺方法简便、可靠，优化的煎煮工艺稳定、可行；壮骨方煮散煎出效果优于传统饮片。 |
| ABSTRACT： | OBJECTIVE： To optimize the decoction technology of Zhuanggufang decoction powder. METHODS： Central composite design with 2 factors and 5 levels was conducted to design the test， taking water （fold） and decoction time as independent variables， the extraction amount of icariin and extraction yield overall desirability value of as dependent variables， regression equation were fitted； response surface method was used to optimize the decoction technology of Zhuanggufang decoction powder， and was verified. It was compared with the traditional decoction piece effect. RESULTS： The optimized technology was decocted twice with 16-fold water， 20 min each time； relative error of predicted and theoretical value by overall desirability value was 2.97％； after decoction powder and piece decocted in the same conditions， the extraction amounts of icariin were 1.234 3 μg/g and 1.132 4 μg/g， extraction yields were 23.73％ and 17.84％， respectively. CONCLUSIONS： Central composite design-response surface method optimizing decoction technology is simple and reliable， the optimized decoction technology is stable and feasible， and the decoction capability of Zhuanggufang decoction powder is better than the traditional pieces. |
| 期刊： | 2017年第28卷第7期 |
| 作者： | 田元春，李双蕾，杨婧，吴丽如，邓紫娉 |
| AUTHORS： | TIAN Yuanchun，LI Shuanglei，YANG Jing，WU Liru，DENG Zipin |
| 关键字： | 壮骨方；煮散；饮片；星点设计-响应面法；煎煮；工艺优化；淫羊藿苷； 浸膏得率 |
| KEYWORDS： | Zhuanggufang； Decoction powder； Decoction pieces； Central composite design-response surface method； Decoction process； Technology optimization； Icariin； Extraction yield |
| 阅读数： | 268 次 |
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