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奥美沙坦酯对原发性轻中度高血压患者血压变异性及血管内皮功能的影响
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| 篇名： | 奥美沙坦酯对原发性轻中度高血压患者血压变异性及血管内皮功能的影响 |
| TITLE： | |
| 摘要： | 目的：探讨奥美沙坦酯对原发性轻、中度高血压患者血压变异性及血管内皮功能的影响。方法：选取轻、中度原发性高血压患者60例作为研究组，同时选取60例健康志愿者作为对照组。研究组患者口服奥美沙坦酯20 mg，qd，服药4周后若收缩压（SBP）≤140 mmHg、舒张压（DBP）＜90 mmHg， 则继续原剂量服药至12周末；未达目标者，剂量加倍治疗至12周末。治疗前后测量研究组患者平均血压、血压变异性参数及动脉内皮依赖性血管扩张百分率（FMD） 和肱动脉内径百分变化率（NMD），同时检测血清中24 h一氧化氮（NO）、内皮素（ET） 浓度变化，并与对照组比较。结果：与治疗前比较，研究组患者治疗后平均血压、 血压变异性、血清ET水平显著降低，血清NO水平显著上升，FMD、NMD 显著改善，差异均有统计学意义（P＜0.05）；与对照组比较，差异无统计学意义（P＞0.05）。研究组患者中3例有轻度腹泻， 2例有轻度干咳，均未予特殊处理，继续用药均自行缓解。结论：奥美沙坦酯有较好的降压作用且耐受性好，可显著改善患者血管内皮功能。 |
| ABSTRACT： | OBJECTIVE： To explore the effects of olmesartan medoxomil on blood pressure variability （BPV） and vascular endothelial function of patients with mild and moderate essential hypertension. METHODS： Sixty patients with mild and moderate essential hypertension were included in study group， and other 60 healthy volunteers were included in control group. Study group was given olmesartan medoxomil 20 mg orally， qd， for 4 weeks， followed by same dose if their SBP≤140 mmHg and DBP＜90 mmHg till 12th weekend； those patients with SBP＞140 mmHg or DBP≥90 mmHg received double dose till 12th weekend. Average blood pressure， BPV， FMD and NMD of study group were measured before and after treatment as well as the changes in serum concentrations of NO and ET， and then compared with control group. RESULTS： Compared with before treatment， average blood pressure， BPV and ET level of study groups were decreased significantly after treatment， serum level of NO was increased significantly， while FMD and NMD were improved significantly， with statistical significance （P＜0.05）； there was no statistical significance， compared with control group （P＞0.05）. There were 3 cases of mild diarrhea and 2 cases of mild dry cough， and they relieved after medication withont speical treatment. CONCLUSIONS： Olmesartan medoxomil can play a good effect on decreasing blood pressure and is tolerable. It can also improve the vascular endothelial function. |
| 期刊： | 2017年第28卷第5期 |
| 作者： | 王文，周晓斌 |
| AUTHORS： | WANG Wen，ZHOU Xiaobin |
| 关键字： | 奥美沙坦酯；高血压；血压变异性； 血管内皮功能 |
| KEYWORDS： | Olmesartan medoxomil； Hypertension； Blood pressure variability； Vascular endothelial function |
| 阅读数： | 249 次 |
| 本月下载数： | 3 次 |
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