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布地奈德雾化吸入对小儿哮喘急性发作的临床观察
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| 篇名： | 布地奈德雾化吸入对小儿哮喘急性发作的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察布地奈德雾化吸入对小儿哮喘急性发作的疗效与安全性。方法：选取2014年1月－2016年5月我院诊治的哮喘急性发作患儿90例，采用随机数字表法分为观察组和对照组，各45例。对照组患儿给予炎琥宁氯化钠注射液10 mg/（kg·d），ivgtt，qd+阿奇霉素注射液10 mg/（kg·d），ivgtt，qd抗感染等常规治疗；观察组患儿在此基础上给予布地奈德气雾剂0.5 mg，雾化吸入，bid。两组患儿均连续治疗7 d。观察患儿的临床疗效、肺功能指标、T细胞亚群水平、症状缓解时间，并记录不良反应发生情况。结果：观察组患儿的总有效率（91.11％）明显高于对照组（71.11％），差异有统计学意义（P＜0.05）；治疗后，观察组患儿肺功能指标用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC均明显高于对照组，差异有统计学意义（P＜0.05）；观察组患儿CD3+、CD4+和CD4+/CD8+均明显升高，CD8+明显降低，且观察组患儿上述指标较对照组改善更明显，差异均有统计学意义（P＜0.05）。观察组患儿喘息、咳嗽、呼吸困难和肺部哮鸣音等临床症状缓解时间均明显短于对照组，差异有统计学意义（P＜0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：布地奈德雾化吸入对小儿哮喘急性发作的疗效明显，且安全性好。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of budesonide aerosol inhalation for pediatric acute asthma attack. METHODS： Ninety patients diagnosed as acute asthma attack selected from our hospital during Jan. 2014-May 2016 were divided into observation group and control group in accordance with random number table， with 45 cases in each group. Control group was given Potassium sodium dehydroandroandrographolide and sodium chloride injection 10 mg/（kg·d），ivgtt，qd+Azithromycin injection 10 mg/（kg·d），ivgtt，qd for anti-infective therapy. Observation group was additionally given Budesonide aerosol 0.5 mg， aerosol inhalation， bid. Both groups received treatment for consecutive 7 d. Clinical efficacy， lung function index， T cell subgroup， symptom relief time were observed， and the occurrence of ADR was recorded. RESULTS： Total response rate of observation group （91.11％） was significantly higher than that of control group （71.11％）， with statistical significance （P＜0.05）. After treatment， FVC， FEV1 and FEV1/FVC of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）. CD3+， CD4+ and CD4+/CD8+ of observation group were significantly increased， while CD8+ was decreased significantly； above indexes of observation group were improved significantly compared to control group， with statistical significance （P＜0.05）. The time of symptom relief as wheezing， coughing， difficult breathing and lung wheeze in observation group were significantly shorter than in control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Budesonide aerosol inhalation shows significant therapeutic efficacy for pediatric acute asthma attack with good safety. |
| 期刊： | 2017年第28卷第5期 |
| 作者： | 张义堂，王中晓，杨红 |
| AUTHORS： | ZHANG Yitang，WANG Zhongxiao，YANG Hong |
| 关键字： | 布地奈德；小儿哮喘；急性发作；雾化吸入；疗效 |
| KEYWORDS： | Budesonide； Pediatric asthma； Acute attack； Aerosol inhalation； Therapeutic efficacy |
| 阅读数： | 244 次 |
| 本月下载数： | 4 次 |
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