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益肾蠲痹丸致不良反应的文献分析
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| 篇名： | 益肾蠲痹丸致不良反应的文献分析 |
| TITLE： | |
| 摘要： | 目的：对益肾蠲痹丸致不良反应（ADR）进行文献研究，为临床安全用药提供文献依据。方法：以“益肾蠲痹丸”为检索词在中国知网（CNKI）数据库进行全文检索，收集益肾蠲痹丸致ADR的相关文献，归纳并分析其ADR发生情况。结果：共纳入15篇文献，涉及58例患者。患者原发疾病最多为类风湿关节炎（28例，48.28％）；ADR累及器官/系统主要为消化系统（77例次，76.24％），主要临床表现有胃脘不适、恶性呕吐、腹泻等；未见严重的ADR发生。引发ADR的剂量主要为8 g，tid（47例，92.16％）；引发ADR的联合用药情况主要为联合2种药物（33例，56.90％）。58例ADR经处理后均好转，主要处理方法为停药及对症治疗。结论：益肾蠲痹丸虽然可能引发ADR，但基本在停药后症状都能自行消退或经中西医对症治疗后好转，是一种较为安全的抗风湿中成药，但在使用中应加强ADR监测。 |
| ABSTRACT： | OBJECTIVE： To offer the literature basis for clinical safe drug use by literature research about ADR induced by Yishen juanbi pill. METHODS： Using “Yishen juanbi pill” as searching word， related literatures about ADR induced by Yishen juanbi pill were collected from CNKI， and then the occurrence of ADR was summarized and analyzed. RESULTS： A total of 15 literatures were included， involving 58 patients. Primary disease were mainly rheumatoid arthritis （28 cases， 48.28％）； organs/systems involved in ADR were digestive system （77 cases， 76.24％）. Main clinical manifestations were epigastric discomfort， pernicious vomiting， diarrhea， etc. No obvious ADR was found. ADR-inducing dose was mainly 8 g， tid （47 cases， 92.16％）； ADR-inducing drug combination were two-drug combination （33 cases，56.90％）. Fifty-eight cases of ADR were recovered after treatment， and main treatment was drug withdrawal or symptomatic treatment. CONCLUSIONS： Although Yishen juanbi pill may induce ADR， those ADR can disappear spontaneously after drug withdrawal or the symptoms are recovered after symptomatic treatment. Yishen juanbi pill is a relatively safe Chinese patent medicine of anti-inflammatory， but ADR monitoring should be strengthened during application. |
| 期刊： | 2017年第28卷第5期 |
| 作者： | 刘清平，孙骏炜，李楠，韩玉凤，林昌松 |
| AUTHORS： | LIU Qingping，SUN Junwei，LI Nan，HAN Yufeng，LIN Changsong |
| 关键字： | 益肾蠲痹丸；不良反应；文献分析 |
| KEYWORDS： | Yishen juanbi pill； ADR； Literature analysis |
| 阅读数： | 292 次 |
| 本月下载数： | 6 次 |
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