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清热解毒软胶囊体内抗甲型H1N1流感病毒的作用研究
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| 篇名： | 清热解毒软胶囊体内抗甲型H1N1流感病毒的作用研究 |
| TITLE： | |
| 摘要： | 目的：观察清热解毒软胶囊（ADSC）体内抗甲型H1N1流感病毒作用，为其用于临床治疗甲型H1N1流感病毒感染提供实验依据。方法：将BALB/c小鼠随机分为正常对照组，模型对照组，阳性药物高、中、低剂量组[磷酸奥司他韦胶囊，0.04、0.02、0.01 g/（kg·d）]和ADSC高、中、低剂量组[1.5、0.75、0.375 g/（kg·d）]。除正常对照组外，其余各组小鼠均经鼻腔滴入滴度为1.6×10－5.2 的甲型 H1N1 流感病毒悬液复制染毒小鼠模型，造模6～8 h后ig相应药物，每天1次，连续5 d。给药结束后，观察7 d内小鼠体质量变化，计算15 d内小鼠的死亡率、死亡保护率及平均存活天数。另取小鼠，分组、给药同上，末次给药8 h后，测定小鼠肺指数和肺指数抑制率。结果：模型组小鼠体质量从第5天开始明显下降，第8天开始出现死亡（15 d内死亡率为85.7％），肺指数较正常对照组明显升高（P＜0.01）。ADSC和磷酸奥司他韦胶囊均可减缓染毒小鼠体质量下降趋势，降低小鼠死亡率和肺指数，延长小鼠的平均存活天数。其中ADSC高剂量组和阳性药物高、中剂量组小鼠的平均存活天数显著高于模型对照组（P＜0.05）；除ADSC低剂量组外，其余各给药组小鼠的肺指数均显著低于模型对照组（P＜0.05）。结论：ADSC对小鼠具有一定的体内抗甲型H1N1流感病毒的作用。 |
| ABSTRACT： | OBJECTIVE： To observe the antiviral effects of Qingre jiedu soft capsule （ADSC） against influenza A H1N1 virus in vivo， and to provide a experimental support for clinical therapy of influenza A H1N1 virus. METHODS： BALB/c mice were randomly divided into normal control group，model control group， positive drug high-dose， medium-dose and low-dose groups [oseltamivir phosphate capsule， 0.04， 0.02， 0.01 g/（kg·d）] and ADSC high-dose， medium-dose and low-dose groups [1.5， 0.75， 0.375 g/（kg·d）].Except for normal control group， others groups were given influenza A H1N1 virus with titer 1.6×10－5.2 via nasal cavity to induce poisoned mice model； 6-8 h after modeling， they were given relevant medicine intragastrically， once a day， for 5 days. After medication， the change of body weight within 7 d were observed in mice； the mortality and death prevention rate within 15 d， mean survival days （MSDs） were calculated in mice.Other mice were selected and grouped， and they were given same drugs as above. 8 h after last medication， lung index and inhibition rate of lung index were determined in mice.RESULTS： In model control group， the body weight of mice decreased significantly since 5th day， and mice death was beginning to occur since 8th day （mortality of 85.7％ within 15 d）； the lung index was increased significantly compared to normal control group （P＜0.01）. Both ADSC and oseltamivir phosphate capsule could slow down the decrease of body weight in mice， decreased the mortality and lung index of mice， and prolonged MSDs； the MSDs of mice in ADSC high-dose，positive drug high-dose and medium-dose groups were significantly higher than model control group （P＜0.05）， and lung index was significantly lower than model control group except that of ADSC low-dose group （P＜0.05）. CONCLUSIONS： ADSC has certain antiviral effect against influenza A H1N1 virus in vivo. |
| 期刊： | 2017年第28卷第4期 |
| 作者： | 贺凤兰，刘强，周杰，刘媛媛，高志峰，肖红，杨占秋 |
| AUTHORS： | HE Fenglan，LIU Qiang，ZHOU Jie，LIU Yuanyuan，GAO Zhifeng，XIAO Hong，YANG Zhanqiu |
| 关键字： | 清热解毒软胶囊；甲型H1N1流感病毒；BALB/c小鼠 |
| KEYWORDS： | Qingre jiedu soft capsule； Influenza A H1N1 virus； BALB/c mice |
| 阅读数： | 260 次 |
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