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贝那普利联合羟苯磺酸钙辅助胰岛素治疗老年早期糖尿病肾病的临床观察
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| 篇名： | 贝那普利联合羟苯磺酸钙辅助胰岛素治疗老年早期糖尿病肾病的临床观察 |
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| 摘要： | 目的： 观察贝那普利联合羟苯磺酸钙辅助胰岛素治疗老年早期糖尿病肾病的疗效和安全性。方法：200例老年早期糖尿病肾病患者随机分为对照组（100例）和观察组（100例）。两组患者均在睡前经胰岛素泵持续皮下注射重组人胰岛素注射液0.4～0.6单位/（kg·d），泵入量为每日总量的50％，其余剂量于每日三餐前平均分配，保证空腹血糖4.4～6.1 mmol/L和餐后2 h血糖4.4～8.0 mmol/L。在此基础上，对照组患者给予盐酸贝那普利片10 mg，口服，每日1次；观察组患者在对照组治疗的基础上给予羟苯磺酸钙胶囊0.5 g，口服，每日3次。两组均连用8周。观察两组患者的临床疗效，治疗前后的肾功能、胱抑素C（Cys-C）、超敏C反应蛋白（hs-CRP）、生活质量核心量表（QLQ-C30）评分及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者肾功能、Cys-C、hs-CRP水平均显著优于同组治疗前，且观察组显著优于对照组；两组患者QOL-C30评分显著高于同组治疗前，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：贝那普利联合羟苯磺酸钙辅助胰岛素治疗老年早期糖尿病肾病的疗效显著，可有效改善临床症状，促进肾功能恢复，提高生活质量，且不会增加不良反应的发生。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of benazepril combined with dobesilate calcium assisted with insulin in the treatment of elderly patients with early diabetic nephropathy. METHODS： 200 elderly patients with early diabetic nephropathy were randomly divided into control group （100 cases） and observation group （100 cases）. All patients received insulin pump continuous subcutaneous injection of Recombinant human insulin injection 0.4-0.6 unit/（kg·d）before going to bed， pumped the total amount of 50％， the other amount was equally distributed before the meals， ensuring fasting blood glucose 4.4-6.1 mmol/L and 2 h postprandial blood glucose 4.4-8.0 mmol/L. Based on it， control group was orally given Benazepril hydrochloride tablet 10 mg， once a day； observation group was additionally given Dobesilate calcium granule 0.5 g， orally， 3 times a day. 2 groups were treated for 8 weeks. Clinical efficacy， renal function， cystatin （Cys） -C， high sensitivity C-reactive protein （hs-CRP）， QLQ-C30 score before and after treatment， and the incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in observation group was significantly higher than control group， with statistical significance （P＜0.05）. After treatment， the renal function indexes， Cys-C and hs-CRP level in 2 groups were significantly better than before， and observation group was better than control group；QOL-C30 score was significantly higher than before， and observation group was higher than control group， with statistical significances （P＜0.05）. And there was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS： Benazepril combined with dobesilate calcium assisted with insulin show obvious efficacy in the treatment of elderly patients with early diabetic nephropathy， which can effectively improve clinical symptoms， promote renal function recovery， improve the quality of life， and do not increase the incidence of adverse reactions. |
| 期刊： | 2017年第28卷第3期 |
| 作者： | 陈攀，白雪 |
| AUTHORS： | CHEN Pan，BAI Xue |
| 关键字： | 贝那普利；羟苯磺酸钙；胰岛素；糖尿病肾病；疗效；安全性 |
| KEYWORDS： | Benazepril； Dobesilate calcium； Insulin； Diabetic nephropathy； Efficacy； Safety |
| 阅读数： | 247 次 |
| 本月下载数： | 3 次 |
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