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唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症的临床观察
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| 篇名： | 唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨唑来膦酸注射液联合金天格胶囊治疗绝经后骨质疏松症（PMOP）的临床疗效及安全性。 方法：选取海南省屯昌县人民医院2012年11月－2015年2月就诊的PMOP患者99例，按照随机数字表法分为对照组、单药组和联合组，各33例。对照组患者给予碳酸钙D3咀嚼片（Ⅱ）2片，po，qd+骨化三醇胶丸0.50 μg，po，bid抗骨质疏松；单药组患者在对照组基础上给予唑来膦酸注射液5 mg，ivgtt，1次/年；联合组患者在单药组基础上给予金天格胶囊1.2 g，po，tid。3组患者均治疗12个月。比较3组患者治疗前后骨密度（BMD）、视觉模拟量表（VAS）评分和日常生活能力量表（ADL）评分，并记录不良反应发生情况。结果：治疗前，3组患者上述指标比较，差异均无统计学意义（P＞0.05）。治疗后，单药组和联合组患者BMD水平均较治疗前明显升高，且明显高于对照组，差异均有统计学意义（P＜0.05）；单药组和联合组患者膝关节、腰背部VAS评分和ADL评分均较治疗前明显降低，且单药组明显低于对照组（ADL评分除外），联合组明显低于单药组，差异均有统计学意义（P＜0.05）。单药组和联合组患者的远期不良反应发生率（6.1％和3.0％）均明显低于对照组（21.2％），差异有统计学意义（P＜0.05）。结论：唑来膦酸注射液联合金天格胶囊可提高PMOP患者BMD，减轻患者膝关节及腰背部疼痛，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To explore clinical efficacy and safety of Zoledronic acid injection combined with Jintiange capsule in the treatment of postmenopausal osteoporosis （PMOP）. METHODS： 99 PMOP patients from Tunchang County People’s Hospital of Hainan Province during Nov. 2012 to Feb. 2015 were selected and divided into control group， single drug group and combination group according to random number table， with 33 cases in each group. Control group received Calcarea carbonica D3 chewable tablets （Ⅱ） 2 tablets， po， qd+Calcitriol soft capsules 0.50 μg， po， bid for osteoporosis； single drug group additionally received Zoledronic acid injection 5 mg，ivgtt，once a year， on the basis of control group； combination group was additionally given Jintiange capsule 1.2 g， po， tid， on the basis of single drug group. 3 groups received treatment for 12 months. BMD， VAS score and ADL score of 3 groups were compared as well as the occurrence of ADR. RESULTS： Before treatment， there was no statistical significance in above indexes of 3 groups （P＞0.05）. After treatment， BMD of single drug group and combination group were increased significantly compared to before treatment， which were significantly higher than that of control group， with statistical significance （P＜0.05）. VAS score and ADL score of knee joint and the small of the back were decreased significantly in single drug group and combination group； the single drug group were significantly lower than the control group （except for ADL score）； the combination group were significantly lower than the single drug group， with statistical significance （P＜0.05）. The incidence of long-term ADR in single drug group and combination group （6.1％， 3.0％） were significantly lower than in control group （21.2％）， with statistical significance （P＜0.05）. CONCLUSIONS： Zoledronic acid injection combined with Jintiange capsules could improve BMD of PMOP patients， relieving pain of knee and back with good safety. |
| 期刊： | 2017年第28卷第2期 |
| 作者： | 符琴，贾利平，刘玉珠，王咸菊，王桂 |
| AUTHORS： | FU Qin，JIA Liping，LIU Yuzhu，WANG Xianju，WANG Gui |
| 关键字： | 唑来膦酸；金天格胶囊；绝经后骨质疏松症；骨密度 |
| KEYWORDS： | Zoledronic acid； Jintiange capsules； Postmenopausal osteoporosis； Bone mineral density |
| 阅读数： | 684 次 |
| 本月下载数： | 3 次 |
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