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蒙药芯芭提取物的抗炎、镇痛作用研究
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| 篇名： | 蒙药芯芭提取物的抗炎、镇痛作用研究 |
| TITLE： | |
| 摘要： | 目的：考察蒙药芯芭提取物的抗炎、镇痛作用。方法：将96只KM小鼠或SD大鼠随机分为模型组（水），阳性对照组（阿司匹林，0.5 g/kg），芯芭醇提物（70％乙醇提取）低、中、高剂量组（0.325、0.650、1.300 g/kg，以生药计）和芯芭醇提后残渣水提物低、中、高剂量组（0.325、0.650、1.300 g/kg，以生药计），每组12只；ig给药，每天1次，连续7 d。分别采用二甲苯致小鼠耳肿胀法测定小鼠耳肿胀度和蛋清致大鼠足肿胀法测定大鼠致炎1、2、4、6 h后的足跖肿胀度，以考察芯芭提取物的抗炎作用。取96只KM小鼠同法分组、给药，采用乙酸扭体法测定小鼠20 min内扭体次数；另取64只KM小鼠，同法分组，每组8只，除阳性对照组小鼠ig盐酸曲马多（0.5 g/kg）外，其余各组小鼠同法给药，采用热板法测定小鼠给药前及给药30、45、60、90 min后的痛阈值，以考察芯芭提取物的镇痛作用。结果：与模型组比较，芯芭提取物可降低小鼠耳肿胀度和蛋清致炎6 h后大鼠足跖肿胀度，除芯芭醇提后残渣水提物高剂量组大鼠足跖肿胀度降低不显著外，其余各组差异均有统计学意义（P＜0.05或P＜0.01）；芯芭提取物可显著减少小鼠20 min内扭体次数，延长给药30、60、90 min后的小鼠痛阈值（P＜0.05）。结论：芯芭醇提物及其醇提残渣水提物均具有一定的抗炎、镇痛作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the anti-inflammatory and analgesic effects of mongolian medicine Cymbaria dahurica extract. METHODS： 96 KM mice （or SD rats） were randomly divided into model group （water）， positive control group （aspirin， 0.5 g/kg）， C. dahurica ethanol extract （70％ ethanol） low-dose， medium-dose and high-dose groups （0.325， 0.650， 1.300 g/kg， calculated by crude drug） and C. dahurica aqueous extract of the residue of alcohol extraction low-dose， medium-dose and high-dose groups （0.325， 0.650， 1.300 g/kg， calculated by crude drug）. They were given relevant medicine intragastrically， once a day， for consecutive 7 d. The xylene-induced ear edema method was used to determine the degree of ear edema， and egg white-induced paw edema method was used to determine paw edema after inducing inflammation 1， 2， 4， 6 h； anti-inflammatory activity of C. dahurica extract was investigated. 96 KM mice were grouped and given medicine with same method； the number of writhing within 20 min was determined by acetic acid writhing method. Another 64 KM mice were grouped with same method， with 8 mice in each group； except positive control group was given tramadol hydrochloride （0.5 g/kg） intragastrically， other groups were given relevant medicine with same method. Pain thresholds of mice were determined by hot-plate test before and after medication 30， 45， 60， 90 min， and analgesic effects of C. dahurica extract were investigated. RESULTS： Compared with model group， C. dahurica extract could obviously restrain the ear edema of mice and paw edema of rats 6 h after egg white-induced inflammation. Except paw edema of rats in C. dahurica aqueous extract of the residue of alcohol extraction high-dose group was decreased slightly， there was statistical significance among other groups （P＜0.05 or P＜0.01）. C. dahurica extract decreased the number of writhing in mice within 20 min， and extended pain thresholds of mice 30， 60， 90 min after medication （P＜0.05）. CONCLUSIONS： Both C. dahurica ethanol extract and aqueous extract of the residue of alcohol extraction posses certain anti-inflammatory and analgesic effects. |
| 期刊： | 2017年第28卷第1期 |
| 作者： | 郭佳佳，刘海，朱燕红，任佳秀，梁永红 |
| AUTHORS： | GUO Jiajia，LIU Hai，ZHU Yanhong，REN Jiaxiu，LIANG Yonghong |
| 关键字： | 蒙药；芯芭；提取物；抗炎；镇痛；小鼠；大鼠 |
| KEYWORDS： | Mongolian medicine； Cymbaria dahurica； Extract； Anti-inflammatory effect； Analgesic effects； Mice； Rat |
| 阅读数： | 316 次 |
| 本月下载数： | 6 次 |
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